Oxidized LDL-induced JAB1 influences NF-κB independent inflammatory signaling in human macrophages during foam cell formation

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• 作者：Anja Schwarz ; Gabriel A. Bonaterra ; Hans Schwarzbach…
• 关键词：Atherosclerosis ; JAB1 ; Macrophages ; oxLDL ; Foam cells
• 刊名：Journal of Biomedical Science
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：24
• 期：1
• 全文大小：1632KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine, general;
• 出版者：BioMed Central
• ISSN：1423-0127
• 卷排序：24

文摘

BackgroundOxidized low-density lipoprotein (oxLDL) mediates the transformation of macrophages (MΦ) to cholesterol-rich foam cells and the release of pro-inflammatory cytokines during atherogenesis. JAB1 (Jun activation domain binding protein-1) is present in all stages of human plaques, involved in the Toll-like receptor-mediated activation of p38 mitogen-activated protein kinase (MAPK) and controls nuclear factor-kappa B (NF-κB) activation. Thus, we were interested in the role of JAB1 during foam cell formation of MΦ after oxLDL exposition.