Macular pigment optical density measurements by one-wavelength reflection photometry—influence of cataract surgery on the measurement results
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- 作者：Bogdana Komar (1)
Franziska Georgia Rauscher (1)
Renate Wiedemann (1)
Jens Dawczynski (1) - 关键词：Cataract ; Macular pigment ; One ; wavelength reflection method ; Lutein ; Zeaxanthin ; Age ; related macular degeneration
- 刊名：Graefe's Archive for Clinical and Experimental Ophthalmology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：252
- 期：11
- 页码：1717-1727
- 全文大小：896 KB
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Franziska Georgia Rauscher (1)
Renate Wiedemann (1)
Jens Dawczynski (1)
1. Department of Ophthalmology, University Hospital Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Germany - ISSN：1435-702X
文摘
Purpose The main objective of the present study was the investigation of possible influence of lens opacification on macular pigment optical density (MPOD) measurements. Methods Eighty-six eyes of 64 patients (mean age 73.4 ±?8.3?years) were included in the study. MPOD was prospectively measured using the one-wavelength reflection method (Visucam500, Carl Zeiss Meditec AG) before and after cataract extraction, with implantation of a blue-light filtering intraocular lens (AlconSN60WF). The median of the maximum optical density (MaxOD) and the median of the mean optical density (MeanOD) measurements of macular pigment across the subject group were evaluated. Results Statistically significant differences were noticed between pre-operative and post-operative measurements, the absolute values were generally lower after cataract extraction. The following median (lower/upper quartile) differences across the group were determined: MaxOD ?3.8?% (?6.2 to ?9.1?%), MeanOD ?4.0?% (?4.6 to ?6.6?%). Larger changes were observed in elderly patients [n--5 eyes): MaxOD ?3.4?% (?0.5 to 3.6?%), MeanOD ?3.6?% (?0.5 to ?5.3?%) versus patients ?0?years (n--1 eyes) MaxOD ?0.5?% (?3.2 to ?0.1?%), MeanOD ?7.2?% (?7.8 to ?0.1?%)] and in patients with progressed stage of cataract. MaxOD for lens opacification grade 1 (n-- eyes): ?7.4?% (?2.1 to ?9.6?%), grade 2 (n--6 eyes): ?5.0?% (?4.2 to ?5.3?%), grade 3 (n--1 eyes): ?4.4?% (?5.4 to ?1.4?%), grade 4 (n--5 eyes): ?2.6?% (?3.2 to ?.4?%), and grade 5 (n-- eyes): ?3.5?% (?1.7 to ?8.7?%) and MeanOD for cataract stage 1 (n-- eyes): ?2.6?% (?6.0 to ?6.0?%), stage 2 (n--6 eyes): ?4.1?% (?1.8 to ?6.2?%), stage 3 (n--1 eyes): ?5.7?% (?4.7 to ?4.7?%), stage 4 (n--5 eyes): ?9.5?% (?9.4 to ?6.1?%), and stage 5 (n-- eyes): ?7.0?% (?6.1 to ?1.4?%). Conclusions As established by comparison of pre- to post-operative measurements, cataract presented a strong effect on MPOD measured by one-wavelength reflection method. Particular care should therefore be taken when evaluating MPOD using this method in elderly patients with progressed stage of cataract. Future optimization of correcting parameters of scattered light and consideration of cataract influence may allow more precise evaluation of MPOD.