Genetic polymorphisms and asthma: findings from a case鈥揷ontrol study in the Madeira island population

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• 作者：Anabela Gon莽alves Berenguer ; Ana Teresa Fernandes ; Susana Oliveira…
• 关键词：Asthma ; Madeira ; SNPs ; Susceptibility ; Severity
• 刊名：Biological Research
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：47
• 期：1
• 全文大小：386KB
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• 作者单位：Anabela Gon莽alves Berenguer (5) (9)
  Ana Teresa Fernandes (5)
  Susana Oliveira (6)
  Mariana Rodrigues (7)
  Pedro Ornelas (6)
  Diogo Romeira (6)
  T芒nia Serr茫o (6)
  Alexandra Rosa (5) (8)
  Rita C芒mara (6)
  
  5. Human Genetics Laboratory, University of Madeira, 9000-390, Funchal, Portugal
  9. Department of Computer Science and Engineering, University of Oulu, PL 4500, 90014, Oulu, Finland
  6. Immunoalergology Unit, Dr. N茅lio Mendon莽a Hospital, SESARAM, E.P.E, Funchal, Portugal
  7. Unit of Statistics, Dr. N茅lio Mendon莽a Hospital, SESARAM, E.P.E, Funchal, Portugal
  8. Medical Sciences Unit, Center of Life Sciences, University of Madeira, 9000-390, Funchal, Portugal
  
• 刊物类别：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Scie
• 刊物主题：Life Sciences, general; Cell Biology; Neurosciences; Developmental Biology; Microbiology; Plant Sciences;
• 出版者：BioMed Central
• ISSN：0717-6287

文摘

Background Asthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV₁) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.