Repetitive 5-aminolevulinic acid-mediated photodynamic therapy on human glioma spheroids

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• 作者：Steen J. Madsen ; Chung-Ho Sun ; Bruce J. Tromberg and Henry Hirschberg
• 关键词：glioma ; photodynamic therapy ; 5 ; aminolevulinic acid ; spheroid
• 刊名：Journal of Neuro-Oncology
• 出版年：2003
• 出版时间：2003
• 年：2003
• 卷：62
• 期：3
• 页码：243-250
• 全文大小：109 KB

文摘

The response of human glioma spheroids to repetitive 5-aminolevulinic acid-mediated photodynamic therapy (PDT) was investigated. In all cases, light fluences were kept below toxic thresholds to simulate conditions typically found at 1–2cm depths in brain adjacent to tumor. Significant inhibition of spheroid growth was observed following multiple PDT treatments at sub-threshold light fluences. The effect appears to be insensitive to the treatment intervals investigated (weekly or bi-monthly). In all cases, suppression of growth was observed for the duration of treatment. Low fluence rates (5mWcm–2) appear to be more effective than high fluence rates (25mWcm–2). No evidence of PDT resistance was found in this investigation.