Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

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• 作者：Andrea C Tricco (11)
  Ayman Chit (10) (11)
  Charlene Soobiah (11)
  David Hallett (10)
  Genevieve Meier (10)
  Maggie H Chen (11)
  Mariam Tashkandi (11)
  Chris T Bauch (11)
  Mark Loeb (10) (11)
  
• 关键词：Antigenic variation ; Cross protection ; Influenza A virus ; Influenza B virus ; Meta ; analysis ; Systematic review ; Vaccines
• 刊名：BMC Medicine
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：11
• 期：1
• 全文大小：436KB
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  60. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1741-7015/11/153/prepub
  
• 作者单位：Andrea C Tricco (11)
  Ayman Chit (10) (11)
  Charlene Soobiah (11)
  David Hallett (10)
  Genevieve Meier (10)
  Maggie H Chen (11)
  Mariam Tashkandi (11)
  Chris T Bauch (11)
  Mark Loeb (10) (11)
  
  11. Faculty of Health Sciences, McMaster University, Michael G DeGroote Centre for Learning, Hamilton, Ontario, Canada
  10. McMaster University, Hamilton, Ontario, Canada
  

文摘

Background Influenza vaccines are most effective when the antigens in the vaccine match those of circulating strains. However, antigens contained in the vaccines do not always match circulating strains. In the present work we aimed to examine the vaccine efficacy (VE) afforded by influenza vaccines when they are not well matched to circulating strains. Methods We identified randomized clinical trials (RCTs) through MEDLINE, EMBASE, the Cochrane Library, and references of included RCTs. RCTs reporting laboratory-confirmed influenza among healthy participants vaccinated with antigens of matching and non-matching influenza strains were included. Two independent reviewers screened citations/full-text articles, abstracted data, and appraised risk of bias. Conflicts were resolved by discussion. A random effects meta-analysis was conducted. VE was calculated using the following formula: (1 - relative risk × 100%). Results We included 34 RCTs, providing data on 47 influenza seasons and 94,821 participants. The live-attenuated influenza vaccine (LAIV) showed significant protection against mismatched (six RCTs, VE 54%, 95% confidence interval (CI) 28% to 71%) and matched (seven RCTs, VE 83%, 95% CI 75% to 88%) influenza strains among children aged 6 to 36 months. Differences were observed between the point estimates for mismatched influenza A (five RCTs, VE 75%, 95% CI 41% to 90%) and mismatched influenza B (five RCTs, VE 42%, 95% CI 22% to 56%) estimates among children aged 6 to 36 months. The trivalent inactivated vaccine (TIV) also afforded significant protection against mismatched (nine RCTs, VE 52%, 95% CI 37% to 63%) and matched (eight RCTs, VE 65%, 95% CI 54% to 73%) influenza strains among adults. Numerical differences were observed between the point estimates for mismatched influenza A (five RCTs, VE 64%, 95% CI 23% to 82%) and mismatched influenza B (eight RCTs, VE 52%, 95% CI 19% to 72%) estimates among adults. Statistical heterogeneity was low (I2 <50%) across all meta-analyses, except for the LAIV meta-analyses among children (I2 = 79%). Conclusions The TIV and LAIV vaccines can provide cross protection against non-matching circulating strains. The point estimates for VE were different for matching versus non-matching strains, with overlapping CIs.