A rare case of renal thrombotic microangiopathy associated with Castleman’s disease
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- 作者：Anubha Mutneja ; L. Nicholas Cossey ; Helen Liapis ; Ying Maggie Chen
- 关键词：Thrombotic microangiopathy ; Castleman’s disease ; VEGF ; Podocytes
- 刊名：BMC Nephrology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：1090KB
- 刊物主题：Nephrology; Internal Medicine;
- 出版者：BioMed Central
- ISSN：1471-2369
- 卷排序：18
文摘
BackgroundCastleman’s disease (CD) is an uncommon, heterogeneous lympho-proliferative disorder leading to high circulating levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF). Renal involvement has been only described in a limited number of small studies. Herein, we report a rare case of renal thrombotic microangiopathy (TMA) associated with CD and investigate the podocyte expression of VEGF in the renal biopsy prior to initiation of treatment.