Pathways of the Maillard reaction under physiological conditions

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• 作者：Christian Henning ; Marcus A. Glomb
• 刊名：Glycoconjugate Journal
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：33
• 期：4
• 页码：499-512
• 全文大小：768 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-4986
• 卷排序：33

文摘

Initially investigated as a color formation process in thermally treated foods, nowadays, the relevance of the Maillard reaction in vivo is generally accepted. Many chronic and age-related diseases such as diabetes, uremia, atherosclerosis, cataractogenesis and Alzheimer’s disease are associated with Maillard derived advanced glycation endproducts (AGEs) and α-dicarbonyl compounds as their most important precursors in terms of reactivity and abundance. However, the situation in vivo is very challenging, because Maillard chemistry is paralleled by enzymatic reactions which can lead to both, increases and decreases in certain AGEs. In addition, mechanistic findings established under the harsh conditions of food processing might not be valid under physiological conditions. The present review critically discusses the relevant α-dicarbonyl compounds as central intermediates of AGE formation in vivo with a special focus on fragmentation pathways leading to formation of amide-AGEs.KeywordsMaillard reactionCarbohydrate chemistryAdvanced glycation endproducts AGEFragmentation pathwaysβ-Dicarbonyl cleavageAmide-AGEsOxidative stress