Development of a novel murine model for treatment of infected mesh scenarios

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• 作者：Arnab Majumder ; Clayton C. Petro ; Lijia Liu ; Mojtaba Fayezizadeh&#8230
• 关键词：Infected mesh ; Contamination ; Murine model ; Synthetic ; Biologic ; Hernia repair
• 刊名：Surgical Endoscopy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：31
• 期：2
• 页码：922-927
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Surgery; Gynecology; Gastroenterology; Hepatology; Proctology; Abdominal Surgery;
• 出版者：Springer US
• ISSN：1432-2218
• 卷排序：31

文摘

BackgroundIndications regarding hernia repair after removal of previously infected prostheses remain unclear. Patients may receive staged primary repair or single-stage reconstructions, neither of which may be ideal. Although animal models have simulated contamination by direct inoculation of implants with bacteria, there remains a paucity of literature, which simulates a field following mesh infection and removal. We aimed to develop a murine model to mimic this complex scenario to allow for further testing of various implants.