Prevalence and clinical manifestations of gastro-oesophageal reflux-associated chronic cough in the Japanese population

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• 作者：Hisako Matsumoto (1)
  Akio Niimi (1)
  Masaya Takemura (1)
  Tetsuya Ueda (1)
  Masafumi Yamaguchi (1)
  Hirofumi Matsuoka (1)
  Makiko Jinnai (1)
  Kazuo Chin (1)
  Michiaki Mishima (1)
  
• 刊名：Cough
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：3
• 期：1
• 全文大小：157KB
• 参考文献：1. Fontana GA, Pistolesi M: Cough. 3: chronic cough and gastro-oesophageal reflux. / Thorax 2003,58(12):1092-095. CrossRef
  2. Irwin RS: Chronic cough due to gastroesophageal reflux disease: ACCP evidence-based clinical practice guidelines. / Chest 2006,129(1 Suppl):80S-94S. CrossRef
  3. Matsumoto H, Niimi A, Satou S, Kishi K: [Chronic cough caused by gastroesophageal reflux]. / Nihon Kokyuki Gakkai Zasshi 2000,38(6):461-65.
  4. McGarvey LP, Heaney LG, Lawson JT, Johnston BT, Scally CM, Ennis M, Shepherd DR, MacMahon J: Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. / Thorax 1998,53(9):738-43. CrossRef
  5. Niimi A, Amitani R, Suzuki K, Tanaka E, Murayama T, Kuze F: Eosinophilic inflammation in cough variant asthma. / Eur Respir J 1998,11(5):1064-069. CrossRef
  6. The committee for The Japanese Respiratory Society guidelines for management of cough: Prolonged and chronic cough. / Respirology 2006, 11:S160-S174. CrossRef
  7. Niimi A: Geography and cough aetiology. / Pulmonary Pharmacology & Therapeutics, / in press.
  8. Fujimura M, Mizuguchi M, Nakatsumi Y, Mizuhashi K, Sasaki S, Yasui M: Addition of a 2-month low-dose course of levofloxacin to long-term erythromycin therapy in sinobronchial syndrome. / Respirology 2002,7(4):317-24. CrossRef
  9. Fujimura M, Ogawa H, Nishizawa Y, Nishi K: Comparison of atopic cough with cough variant asthma: is atopic cough a precursor of asthma? / Thorax 2003,58(1):14-8. CrossRef
  10. WHO::Global Database on Body Mass Index: [www.who.int/bmi/index.jsp]
  11. Furukawa N, Iwakiri R, Koyama T, Okamoto K, Yoshida T, Kashiwagi Y, Ohyama T, Noda T, Sakata H, Fujimoto K: Proportion of reflux esophagitis in 6010 Japanese adults: prospective evaluation by endoscopy. / J Gastroenterol 1999,34(4):441-44. CrossRef
  12. Mishima I, Adachi K, Arima N, Amano K, Takashima T, Moritani M, Furuta K, Kinoshita Y: Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese. / Scand J Gastroenterol 2005,40(9):1005-009. CrossRef
  13. Heading RC: Prevalence of upper gastrointestinal symptoms in the general population: a systematic review. / Scand J Gastroenterol Suppl 1999, 231:3-.
  14. Jaspersen D, Kulig M, Labenz J, Leodolter A, Lind T, Meyer-Sabellek W, Vieth M, Willich SN, Lindner D, Stolte M, Malfertheiner P: Prevalence of extra-oesophageal manifestations in gastro-oesophageal reflux disease: an analysis based on the ProGERD Study. / Aliment Pharmacol Ther 2003,17(12):1515-520. CrossRef
  15. Irwin RS, Zawacki JK, Curley FJ, French CL, Hoffman PJ: Chronic cough as the sole presenting manifestation of gastroesophageal reflux. / Am Rev Respir Dis 1989,140(5):1294-300.
  16. Kiljander TO, Salomaa ER, Hietanen EK, Terho EO: Chronic cough and gastro-oesophageal reflux: a double-blind placebo-controlled study with omeprazole. / Eur Respir J 2000,16(4):633-38. CrossRef
  17. Ing AJ, Breslin AB: The patient with chronic cough. / Med J Aust 1997,166(9):491-96.
  
• 作者单位：Hisako Matsumoto (1)
  Akio Niimi (1)
  Masaya Takemura (1)
  Tetsuya Ueda (1)
  Masafumi Yamaguchi (1)
  Hirofumi Matsuoka (1)
  Makiko Jinnai (1)
  Kazuo Chin (1)
  Michiaki Mishima (1)
  
  1. Department of Respiratory Medicine, Kyoto University, Kyoto, Japan
  

文摘

Gastro-oesophageal reflux (GOR) is one of the most common causes of chronic cough in Western countries, responsible for 10 to 40% of cases. In Japan, however, GOR-associated chronic cough (GOR-CC) has been rarely reported and its clinical manifestation including frequency of concomitant reflux laryngitis is poorly known. We have analyzed prevalence and clinical characteristics of patients who were diagnosed as having GOR-CC among adult patients with chronic cough (?8 weeks) who visited our asthma and cough clinic over a period of 19 months. Diagnosis of GOR-CC was based on the response of coughing to a proton-pump inhibitor (lansoprazole? and/or positive results of 24 h ambulatory esophageal pH monitoring. Laryngeal involvement was based on symptoms or objective diagnosis by specialists. GOR-associated chronic cough was diagnosed in 7.1% (8 of 112) of chronic cough patients. In addition to the demographic data which were consistent with the characteristics of patients with GOR-CC in the Western populations, including gender (6 females), age (mean ± SE, 56.9 ± 5.8 years), duration of cough (9.9 ± 3.3 months), lack of gastrointestinal symptoms (3 of 8) and complication with other causes of cough (5 of 8), we found the standard range of body mass index (23.9 ± 1.5 kg/m2) and high incidence of concomitant reflux laryngitis (5 of 8) in the present 8 patients. Among 4 patients who could stop treatment with temporal resolution of cough, cough recurred in 3 patients, 1 week to 8 months after the discontinuation. In conclusion, GOR-CC is a less frequent cause of chronic cough in Japan than in Western countries. Signs or symptoms of laryngitis may be important as clues to suspicion of GOR-CC.