Scanning electron microscopic analysis of polymer damage in drug-eluting stents during multiple stenting

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• 作者：Aiko Shimokado (1)
  Takashi Kubo (1)
  Hirotoshi Utsunomiya (2)
  Hisashi Yamasaki (3)
  Takashi Tanimoto (1)
  Yasushi Ino (1)
  Yong Liu (1)
  Ikuko Teraguchi (1)
  Yuichi Ozaki (1)
  Yasutsugu Shiono (1)
  Makoto Orii (1)
  Kunihiro Shimamura (1)
  Takashi Yamano (1)
  Tomoyuki Yamaguchi (1)
  Kumiko Hirata (1)
  Toshio Imanishi (1)
  Takashi Akasaka (1)
  
• 关键词：Drug ; eluting stent ; Polymer damage ; Scanning electron microscopy ; Stent analysis
• 刊名：The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging)
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：29
• 期：8
• 页码：1909-1913
• 全文大小：
• 作者单位：Aiko Shimokado (1)
  Takashi Kubo (1)
  Hirotoshi Utsunomiya (2)
  Hisashi Yamasaki (3)
  Takashi Tanimoto (1)
  Yasushi Ino (1)
  Yong Liu (1)
  Ikuko Teraguchi (1)
  Yuichi Ozaki (1)
  Yasutsugu Shiono (1)
  Makoto Orii (1)
  Kunihiro Shimamura (1)
  Takashi Yamano (1)
  Tomoyuki Yamaguchi (1)
  Kumiko Hirata (1)
  Toshio Imanishi (1)
  Takashi Akasaka (1)
  
  1. Department of Cardiovascular Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-8510, Japan
  2. Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
  3. Division of Biology, Wakayama Medical University, Wakayama, Japan
  
• ISSN：1573-0743

文摘

Polymer damage of drug-eluting stents (DES) during percutaneous coronary intervention procedure could be associated with stent restenosis. We assessed the damage to the drug-containing polymer of DES during multiple stenting in a phantom model by using scanning-electron microscopy (SEM). Unexpanded sirolimus-eluting stent (SES; n?=?15) was delivered through the formerly expanded SES (n?=?15) in a bended polytetrafluoroethylene plastic tube. The stent was subcategorized into 4 segments (S), including distal (S1), mid distal (S2), mid proximal (S3) and proximal segments (S4), for qualitative SEM assessment. Polymer damage, such as detachments, missing or tears, was observed not only in the outer surface of the unexpanded stents (100?%) but also in the inner surface of the formerly expanded stents (100?%). There was a significant difference in the frequency of polymer damage among the 4 segments in the unexpanded stents (S1 vs. S2 vs. S3 vs. S4: 86.7 vs. 80.0 vs. 53.3 vs. 40.0?%, p?=?0.022) and the formerly expanded stents (S1 vs. S2 vs. S3 vs. S4: 80.0 vs. 73.3 vs. 73.3 vs. 40.0?%, p?=?0.041). The damage was distributed more frequently in distal part than proximal part of either unexpanded stents (S1 vs. S4, p?=?0.0079) and the formerly expanded stents (S1 vs. S4, p?=?0.0079). Delivery of DES through a formerly expanded DES could cause damage to drug-containing polymer of the stents.