Efficacy and safety of strong acid electrolyzed water for peritoneal lavage to prevent surgical site infection in patients with perforated appendicitis

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• 作者：Akio Kubota ; Taro Goda ; Tomomitsu Tsuru ; Takeo Yonekura ; Makoto Yagi…
• 关键词：Strong acid electrolyzed water ; Perforated peritonitis ; Surgical site infection ; Peritoneal lavage ; Bactericidal activity ; Hypochlorous acid ; Perforated appendicitis
• 刊名：Surgery Today
• 出版年：2015
• 出版时间：July 2015
• 年：2015
• 卷：45
• 期：7
• 页码：876-879
• 全文大小：391 KB
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  5.Kubota A, Nose K, Yonekura T, Kosumi T, Yamauchi K, Oyanagi H. Effect of electrolyzed strong acid water on peritoneal irrigation of experimental perforated peritonitis. Surg Today. 2009;39:514-.PubMed View Article
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  15.Hayashi H, Kumon K, Yahagi N, Haruna M, Watranabe Y, Matsui J, et al. Successful treatment of mediastinitis after cardiovascular surgery using electrolyzed strong acid aqueous solution. Artif Organs. 1997;21:39-2.PubMed View Article
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• 作者单位：Akio Kubota (1)
  Taro Goda (1)
  Tomomitsu Tsuru (2)
  Takeo Yonekura (3)
  Makoto Yagi (4)
  Hisayoshi Kawahara (1)
  Akihiro Yoneda (1)
  Yuko Tazuke (1)
  Gakuto Tani (1)
  Tomohiro Ishii (1)
  Satoshi Umeda (1)
  Katsuhisa Hirano (1)
  
  1. Department of Pediatric Surgery, Osaka Medical Center and Research Center for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan
  2. Department of Pediatric Surgery, St. Maria Hospital, Kurume, Japan
  3. Department of Pediatric Surgery, Kinki University Nara Hospital, Nara, Japan
  4. Division of Pediatric Surgery, Kinki University School of Medicine, Osaka, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Surgery
  Abdominal Surgery
  Thoracic Surgery
  Vascular Surgery
  Cardiac Surgery
  Surgical Oncology
  
• 出版者：Springer Japan
• ISSN：1436-2813

文摘

Purpose Our previous experimental study of perforated peritonitis in rats proved that peritoneal lavage with strong acid electrolyzed water (SAEW) has no adverse effects, reduces the bacteria count in the ascitic fluid more effectively than saline, and increases the survival rate significantly. Thus, we conducted a randomized controlled study, applying SAEW in the treatment of perforated appendicitis in children. Methods Forty-four patients, aged 3-4?years, were randomly divided into two groups: Group S (n?=?20), in which the peritoneal cavity was lavaged with 100?ml/kg saline and the wound was washed out with 200?ml saline; and Group E (n?=?24), in which the peritoneal cavity was lavaged with 100?ml/kg SAEW and the wound was washed out with 200?ml SAEW. Results No adverse effect of SAEW was observed in Group E. There was no difference in the bacterial evanescence ratio of ascitic fluid after lavage between Groups S and E (11.1 and 15.8?%, respectively). A residual abscess developed in one patient from each group (5.0 and 4.2?%, respectively). The incidence of surgical site infection (SSI) was significantly lower in Group E than in Group S (0 and 20?%, respectively; P?<?0.05). There was no difference in the duration of pyrexia, positive C-reactive protein, leukocytosis, or hospital stay between the groups. Conclusion Peritoneal lavage and wound washing with SAEW have no adverse effects and are effective for preventing SSI.