Full genome sequences of torque teno sus virus strains that coinfected a pig with postweaning multisystemic wasting syndrome in Japan: implications for genetic diversity

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• 作者：Makoto Ozawa ; Toshiko Kawabata ; Kosuke Okuya ; Kiori Nagano…
• 刊名：Archives of Virology
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：160
• 期：12
• 页码：3067-3074
• 全文大小：553 KB
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• 作者单位：Makoto Ozawa (1) (2) (3)
  Toshiko Kawabata (2)
  Kosuke Okuya (1)
  Kiori Nagano (2)
  Takehiro Kanda (1)
  Norihiro Kanazawa (1)
  Kyoko Tsukiyama-Kohara (1) (2) (3)
  Akira Taneno (4)
  Eisaburo Deguchi (1) (3) (5)
  
  1. Laboratory of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima, 890-0065, Japan
  2. Transboundary Animal Diseases Control and Research Center, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan
  3. United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi, Japan
  4. Vaxxinova Japan K.K., Tokyo, Japan
  5. Laboratory of Farm Animal Production Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Virology
  Medical Microbiology
  Infectious Diseases
  
• 出版者：Springer Wien
• ISSN：1432-8798

文摘

We determined the complete genome sequences of torque teno sus viruses (TTSuVs) detected in pigs with postweaning multisystemic wasting syndrome (PMWS) and in healthy pigs in Japan. Unexpectedly, we found coinfection of a PMWS-affected pig in Japan with one strain of TTSuV1, five strains of TTSuV2, and one strain of PCV2. Full-genome sequencing of each of these strains, followed by phylogenetic analysis, revealed broad genetic diversity in the TTSuV2 strains infecting the PMWS-affected pig. These results suggest that the geographical bias in the available genetic information about TTSuVs has a limited impact on the evaluation of their genetic diversity.