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作者单位:Tiffany Hon (1) Ravi K. Das (1) Sunjeev K. Kamboj (1)
1. Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, WC1E 6BT, UK
刊物类别:Biomedical and Life Sciences
刊物主题:Biomedicine Pharmacology and Toxicology Psychiatry
出版者:Springer Berlin / Heidelberg
ISSN:1432-2072
文摘
Rationale Addiction is a disorder of motivational learning and memory. Maladaptive motivational memories linking drug-associated stimuli to drug seeking are formed over hundreds of reinforcement trials and accompanied by aberrant neuroadaptation in the mesocorticolimbic reward system. Such memories are resistant to extinction. However, the discovery of retrieval-dependent memory plasticity has opened up the possibility of permanent modification of established (long-term) memories during ‘reconsolidation’.