The effects of neoadjuvant chemoradiotherapy and an in-hospital exercise training programme on physical fitness and quality of life in locally advanced rectal cancer patients (The EMPOWER Trial): study protocol for a randomised controlled trial

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• 作者：Lisa Loughney ; Malcolm A. West ; Graham J. Kemp ; Harry B. Rossiter…
• 关键词：Neoadjuvant chemoradiotherapy ; Exercise training ; Physical activity ; Surgery ; Surgical outcome
• 刊名：Trials
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,256 KB
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• 作者单位：Lisa Loughney (1) (2)
  Malcolm A. West (1) (2) (4)
  Graham J. Kemp (2) (3)
  Harry B. Rossiter (5) (6)
  Shaunna M. Burke (5)
  Trevor Cox (7)
  Christopher P. Barben (8)
  Michael G. Mythen (9)
  Peter Calverley (10)
  Daniel H. Palmer (11)
  Michael P. W. Grocott (1) (2)
  Sandy Jack (1) (2)
  
  1. Anaesthesia and Critical Care Research Area, NIHR Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, CE93, MP24, Tremona Road, Southampton, SO16 6YD, UK
  2. Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, CE93, MP24, Tremona Road, Southampton, SO16 6YD, UK
  4. Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, South Academic Block, Tremona Road, Southampton, SO16 6YD, UK
  3. Department of Musculoskeletal Biology and MRC – Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA), Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
  5. School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK
  6. Rehabilitation Clinical Trials Center, Division of Respiratory and Critical Care Physiology and Medicine, Los Angles Biomedical Research Institute, 1124 W Carson St, Torrance, CA, 90502, USA
  7. Departments of Molecular and Clinical Cancer Medicine and Biostatistics, University of Liverpool, Liverpool, UK
  8. Colorectal Surgery Research Group, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK
  9. Anaesthesia and Critical Care, University College London, London, UK
  10. Institute of Ageing and Chronic Disease, Aintree University Hospital, Liverpool, UK
  11. Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, UK and The Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, UK
  
• 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：1745-6215

文摘

Background The standard treatment pathway for locally advanced rectal cancer is neoadjuvant chemoradiotherapy (CRT) followed by surgery. Neoadjuvant CRT has been shown to decrease physical fitness, and this decrease is associated with increased post-operative morbidity. Exercise training can stimulate skeletal muscle adaptations such as increased mitochondrial content and improved oxygen uptake capacity, both of which are contributors to physical fitness. The aims of the EMPOWER trial are to assess the effects of neoadjuvant CRT and an in-hospital exercise training programme on physical fitness, health-related quality of life (HRQoL), and physical activity levels, as well as post-operative morbidity and cancer staging.