Synthesis of 3,5-disubstituted 1,2,4-triazoles containing an amino group

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• 作者：N. Yu. Khromova ; M. M. Fedorov ; S. I. Malekin&#8230
• 刊名：Russian Journal of Organic Chemistry
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：52
• 期：10
• 页码：1490-1495
• 全文大小：
• 刊物主题：Organic Chemistry;
• 出版者：Pleiades Publishing
• ISSN：1608-3393
• 卷排序：52

文摘

3,5-Disubstituted 1,2,4-triazoles containing linear and cyclic amine fragments have been synthesized by thermal cyclization of N′-(1-iminoalkyl) hydrazides prepared by condensation of imido esters with carboxylic acid hydrazides. The initial imido esters have been synthesized by the Pinner reaction, as well as by reaction of nitriles with methanol in the presence of a catalytic amount of sodium methoxide. A procedure has been developed for the synthesis of 5-substituted 3-(3-nitrophenyl)-1,2,4-triazoles which have been converted to 3-aminophenyl derivatives by reduction with hydrazine hydrate over Raney nickel.