Amino acid and peptide chemistry on silicones

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• 作者：Frank J. LaRonde ; Michael A. Brook and Gang Hu
• 关键词：functional silicones ; amino acids ; peptides
• 刊名：Silicon Chemistry
• 出版年：2002
• 出版时间：2002
• 年：2002
• 卷：1
• 期：3
• 页码：215-222
• 全文大小：115 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Inorganic Chemistry
  Polymer Sciences
  Organic Chemistry
  Physical Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-8994

文摘

Poly(dimethylsiloxanes), di-terminated with amino acids, were synthesized by employing the Diels-Alder reaction of cyclopentadiene- or furan-terminated poly(dimethylsiloxanes) with functional dienophiles including N-maleoyl-protected phenylalanine. The amino acid could be chain extended using conventional solution peptide coupling with DCC, DMAP and N-hydroxysuccinimide to give a dipeptide-terminated silicone. The molecular weight of the silicone component of the telechelic system could be increased by acid-catalyzed redistribution with octamethylcyclotetrasiloxane (D₄).