18F-FDG PET of the hands with a dedicated high-resolution PEM system (arthro-PET): correlation with PET/CT, radiography and clinical parameters
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- 作者：Joyce C. Mhlanga (1)
John A. Carrino (2)
Martin Lodge (1)
Hao Wang (3)
Richard L. Wahl (1) (4) - 关键词：PET/CT ; Positron emission mammography (PEM) ; Osteoarthritis (OA) ; Arthritis ; 18F ; Fluoro ; 2 ; deoxy ; D ; glucose (FDG)
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：41
- 期：12
- 页码：2337-2345
- 全文大小：687 KB
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16. Elzinga EH, van der Laken CJ, Comans EF, Lammertsma AA, Dijkmans BA, Voskuyl AE. 2-Deoxy-2-[F-18]fluoro-D-glucose joint up - 作者单位：Joyce C. Mhlanga (1)
John A. Carrino (2)
Martin Lodge (1)
Hao Wang (3)
Richard L. Wahl (1) (4)
1. Division of Nuclear Medicine, The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
2. Division of Musculoskeletal Radiology, The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
3. Department of Oncology Biostatistics Division, Johns Hopkins University School of Medicine, Baltimore, MD, USA
4. Division of Nuclear Medicine, Johns Hopkins University Hospitals, 601 N. Caroline Street, JHOC 3233, Baltimore, MD, 21287-0817, USA - ISSN：1619-7089
文摘
Purpose The aim of this study was to prospectively determine the feasibility and compare the novel use of a positron emission mammography (PEM) scanner with standard PET/CT for evaluating hand osteoarthritis (OA) with 18F-FDG. Methods Institutional review board approval and written informed consent were obtained for this HIPAA-compliant prospective study in which 14 adults referred for oncological 18F-FDG PET/CT underwent dedicated hand PET/CT followed by arthro-PET using the PEM device. Hand radiographs were obtained and scored for the presence and severity of OA. Summed qualitative and quantitative joint glycolytic scores for each modality were compared with the findings on plain radiography and clinical features. Results Eight patients with clinical and/or radiographic evidence of OA comprised the OA group (mean age 73?±-.7?years). Six patients served as the control group (53.7?±-.3?years). Arthro-PET quantitative and qualitative joint glycolytic scores were highly correlated with PET/CT findings in the OA patients (r--.86. p?--.007; r--.94, p--.001). Qualitative arthro-PET and PET/CT joint scores were significantly higher in the OA patients than in controls (38.7?±-.6 vs. 32.2?±-.4, p--.02; 37.5?±-.4 vs. 32.2?±-.4, p--.03, respectively). Quantitative arthro-PET and PET/CT maximum SUV-lean joint scores were higher in the OA patients, although they did not reach statistical significance (20.8?±-.2 vs. 18?±-.8, p--.13; 22.8?±-.38 vs. 20.1?±-.54, p=-.21). By definition, OA patients had higher radiographic joint scores than controls (30.9?±-1.3 vs. 0, p--.03). Conclusion Hand imaging using a small field of view PEM system (arthro-PET) with FDG is feasible, performing comparably to PET/CT in assessing metabolic joint activity. Arthro-PET and PET/CT showed higher joint FDG uptake in OA. Further exploration of arthro-PET in arthritis management is warranted.