Invasive Propionibacterium acnes infections in a non-selective patient cohort: clinical manifestations, management and outcome

详细信息    查看全文

• 作者：M. Tebruegge ; C. Jones ; H. de Graaf…
• 刊名：European Journal of Clinical Microbiology & Infectious Diseases
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：34
• 期：3
• 页码：527-534
• 全文大小：296 KB
• 参考文献：1. Jahns, AC, Lundskog, B, Ganceviciene, R, Palmer, RH, Golovleva, I, Zouboulis, CC (2012) An increased incidence of Propionibacterium acnes biofilms in acne vulgaris: a case–control study. Br J Dermatol 167: pp. 50-58 CrossRef
  2. Grice, EA, Segre, JA (2011) The skin microbiome. Nat Rev Microbiol 9: pp. 244-253 CrossRef
  3. Grice, EA, Kong, HH, Conlan, S, Deming, CB, Davis, J, Young, AC (2009) Topographical and temporal diversity of the human skin microbiome. Science 324: pp. 1190-1192 CrossRef
  4. Kurokawa, I, Danby, FW, Ju, Q, Wang, X, Xiang, LF, Xia, L (2009) New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol 18: pp. 821-832 CrossRef
  5. Coenye, T, Peeters, E, Nelis, HJ (2007) Biofilm formation by Propionibacterium acnes is associated with increased resistance to antimicrobial agents and increased production of putative virulence factors. Res Microbiol 158: pp. 386-392 CrossRef
  6. Sohail, MR, Gray, AL, Baddour, LM, Tleyjeh, IM, Virk, A (2009) Infective endocarditis due to Propionibacterium species. Clin Microbiol Infect 15: pp. 387-394 CrossRef
  7. Ito, K, Ito, Y, Mizuta, K, Ogawa, H, Suzuki, T, Miyata, H (1995) Bacteriology of chronic otitis media, chronic sinusitis, and paranasal mucopyocele in Japan. Clin Infect Dis 20: pp. S214-S219 CrossRef
  8. Brook, I (1994) Infection caused by Propionibacterium in children. Clin Pediatr (Phila) 33: pp. 485-490 CrossRef
  9. Brook, I, Frazier, EH (1991) Infections caused by Propionibacterium species. Rev Infect Dis 13: pp. 819-822 CrossRef
  10. Asseray, N, Papin, C, Touchais, S, Bemer, P, Lambert, C, Boutoille, D (2010) Improving diagnostic criteria for Propionibacterium acnes osteomyelitis: a retrospective analysis. Scand J Infect Dis 42: pp. 421-425 CrossRef
  11. Conen, A, Walti, LN, Merlo, A, Fluckiger, U, Battegay, M, Trampuz, A (2008) Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period. Clin Infect Dis 47: pp. 73-82 CrossRef
  12. Kanafani, ZA, Sexton, DJ, Pien, BC, Varkey, J, Basmania, C, Kaye, KS (2009) Postoperative joint infections due to Propionibacterium species: a case–control study. Clin Infect Dis 49: pp. 1083-1085 CrossRef
  13. Uckay, I, Dinh, A, Vauthey, L, Asseray, N, Passuti, N, Rottman, M (2010) Spondylodiscitis due to Propionibacterium acnes: report of twenty-nine cases and a review of the literature. Clin Microbiol Infect 16: pp. 353-358 CrossRef
  14. Arnell, K, Cesarini, K, Lagerqvist-Widh, A, Wester, T, Sjolin, J (2008) Cerebrospinal fluid shunt infections in children over a 13-year period: anaerobic cultures and comparison of clinical signs of infection with Propionibacterium acnes and with other bacteria. J Neurosurg Pediatr 1: pp. 366-372 CrossRef
  15. Nisbet, M, Briggs, S, Ellis-Pegler, R, Thomas, M, Holland, D (2007) Propionibacterium acnes: an under-appreciated cause of post-neurosurgical infection. J Antimicrob Chemother 60: pp. 1097-1103 CrossRef
  16. Zeller, V, Ghorbani, A, Strady, C, Leonard, P, Mamoudy, P, Desplaces, N (2007) Propionibacterium
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Medical Microbiology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1435-4373

文摘

An increasing number of reports suggest that Propionibacterium acnes can cause serious invasive infections. Currently, only limited data exist regarding the spectrum of invasive P. acnes infections. We conducted a non-selective cohort study at a tertiary hospital in the UK over a 9-year-period (2003-012) investigating clinical manifestations, risk factors, management, and outcome of invasive P. acnes infections. Forty-nine cases were identified; the majority were neurosurgical infections and orthopaedic infections (n-/em>=-8 and n--5 respectively). Only 2 cases had no predisposing factors; all neurosurgical and 93.3?% of orthopaedic cases had a history of previous surgery and/or trauma. Foreign material was in situ at the infection site in 59.3?% and 80.0?% of neurosurgical and orthopaedic cases respectively. All neurosurgical and orthopaedic cases required one or more surgical interventions to treat P. acnes infection, with or without concomitant antibiotic therapy; the duration of antibiotic therapy was significantly longer in the group of orthopaedic cases (median 53 vs 19?days; p--.0025). All tested P. acnes isolates were susceptible to penicillin, ampicillin and chloramphenicol; only 1 was clindamycin-resistant. Neurosurgical and orthopaedic infections account for the majority of invasive P. acnes infections. Most cases have predisposing factors, including previous surgery and/or trauma; spontaneous infections are rare. Foreign material is commonly present at the site of infection, indicating that the pathogenesis of invasive P. acnes infections likely involves biofilm formation. Since invasive P. acnes infections are associated with considerable morbidity, further studies are needed to establish effective prevention and optimal treatment strategies.