Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model
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- 作者：Robert Müller (1)
Marian Kampschulte (2)
Thaqif El Khassawna (3)
Gudrun Schlewitz (4)
Britta Hürter (3)
Wolfgang B?cker (3) (4)
Manfred Bobeth (1)
Alexander C. Langheinrich (5)
Christian Heiss (3) (4)
Andreas Deutsch (6)
Gianaurelio Cuniberti (1) - 关键词：Osteoporosis ; Biomechanics ; Young’s modulus ; Bone histology ; Rat model
- 刊名：Medical and Biological Engineering and Computing
- 出版年：2014
- 出版时间：April 2014
- 年：2014
- 卷：52
- 期：4
- 页码：405-414
- 全文大小：2,480 KB
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Marian Kampschulte (2)
Thaqif El Khassawna (3)
Gudrun Schlewitz (4)
Britta Hürter (3)
Wolfgang B?cker (3) (4)
Manfred Bobeth (1)
Alexander C. Langheinrich (5)
Christian Heiss (3) (4)
Andreas Deutsch (6)
Gianaurelio Cuniberti (1)
1. Institute for Materials Science and Max Bergmann Center of Biomaterials, Dresden University of Technology, 01062, Dresden, Germany
2. Department of Radiology, University Hospital of Giessen-Marburg, Giessen, Germany
3. Laboratory of Experimental Trauma Surgery, Justus-Liebig University, Giessen, Germany
4. Department of Trauma Surgery, University Hospital of Giessen-Marburg, Giessen, Germany
5. Department of Diagnostic and Interventional Radiology, BG Trauma Hospital, Frankfurt/Main, Germany
6. Center for Information Services and High Performance Computing, Dresden University of Technology, 01062, Dresden, Germany - ISSN：1741-0444
文摘
For assessing mechanical properties of osteoporotic bone, biomechanical testing combined with in silico modeling plays a key role. The present study focuses on microscopic mechanical bone properties in a rat model of postmenopausal osteoporosis. Female Sprague–Dawley rats were (1) euthanized without prior interventions, (2) sham-operated, and (3) subjected to ovariectomy combined with a multi-deficiencies diet. Rat vertebrae (corpora vertebrae) were imaged by micro-CT, their stiffness was determined by compression tests, and load-induced stress states as well as property changes due to the treatment were analyzed by finite-element modeling. By comparing vertebra stiffness measurements with finite-element calculations of stiffness, an overall microscopic Young’s modulus of the bone was determined. Macroscopic vertebra stiffness as well as the microscopic modulus diminish with progression of osteoporosis by about 70?%. After strong initial changes of bone morphology, further decrease in macroscopic stiffness is largely due to decreasing microscopic Young’s modulus. The micromechanical stress calculations reveal particularly loaded vertebra regions prone to failure. Osteoporosis-induced changes of the microscopic Young’s modulus alter the fracture behavior of bone, may influence bone remodeling, and should be considered in the design of implant materials.