Skin manifestations of Cushing’s syndrome

详细信息    查看全文

• 作者：Constantine A. Stratakis
• 关键词：Cushing’s syndrome ; Glucocorticoids ; Skin ; Acne ; Plethora ; Hyperpigmentation ; Bruise ; Striae ; Hirsutism ; Acanthosis
• 刊名：Reviews in Endocrine and Metabolic Disorders
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：17
• 期：3
• 页码：283-286
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Endocrinology; Diabetes; Internal Medicine;
• 出版者：Springer US
• ISSN：1573-2606
• 卷排序：17

文摘

Among the most common diagnostic manifestations of Cushing’s syndrome (CS) are those involving the skin; they include violaceous striae, facial acne, hirsutism, acanthosis nigricans (AN), fungal infections, hyperpigmentation (Hp) and easy bruisability. Fortunately, most resolve within a year or two after cure of CS, although light-colored striae can persist for years depending on the age of the patients. AN, Hp, and bruisability usually resolve within months after cure in almost all ages. Facial plethora (along with acne and other facial skin changes) is a typical sign of CS that is due to increased perfusion. It resolves immediately after curative therapy of CS. Typically, the severity of the manifestations does not correlate with the biochemical indices of the disease, pointing to age, gender, genetic and skin-type differences that determine the cutaneous manifestations of CS.