Incidence of infusion reactions to anti-neoplastic agents in early phase clinical trials: The MD Anderson Cancer Center experience
详细信息 查看全文
- 作者：Manojkumar Bupathi ; Joud Hajjar ; Stacie Bean ; Siqing Fu…
- 关键词：Anti ; neoplastic agent ; Cytokine reaction ; Hypersensitivity ; Infusion reaction ; Monoclonal antibody ; Phase I
- 刊名：Investigational New Drugs
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：35
- 期：1
- 页码：59-67
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology; Pharmacology/Toxicology;
- 出版者：Springer US
- ISSN：1573-0646
- 卷排序：35
文摘
Infusion reactions (IRs) to anti-neoplastic agents require prompt recognition and immediate treatment to avert significant complications. We conducted a retrospective review of the medical records of consecutive patients who received anti-neoplastic therapy in the outpatient treatment center of the Department of Investigational Cancer Therapeutics from January 1, 2013 to November 30, 2013. Of the 597 patients who received treatment, 9 (1.5 %) had IRs (all ≤ grade 2). The most common IRs observed on first occurrence were chills (n = 5), itching, rash, and facial flushing (n = 3 each). There were no IR-related deaths. All the IRs were reversible with appropriate symptomatic treatment and the therapy was completed after temporary cessation of infusion in 7 of the 9 patients. The infusion was stopped in 2 patients due to symptoms suggestive of IgE-mediated allergic reaction and cytokine storm. Five of the 8 patients who were re-challenged with the same therapy developed a similar reaction. However, the infusion was completed in 4 of the 5 patients after administration of intravenous diphenhydramine and/or hydrocortisone, or slowing the rate of infusion. And, subsequent cycles with the same agents were uneventful. IRs to anti-neoplastic agents are rare. Though the clinical presentations are overlapping, most IRs are not IgE-mediated allergic reactions. Appropriate premedication and slow rate of infusion facilitates uneventful administration of the anti-neoplastic agents in subsequent cycles. Further study in a larger cohort of patients to identify biomarkers of hypersensitivity is warranted.