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作者单位:Bioinformatics and Biomedical Engineering
丛书名:978-3-319-16482-3
刊物类别:Computer Science
刊物主题:Artificial Intelligence and Robotics Computer Communication Networks Software Engineering Data Encryption Database Management Computation by Abstract Devices Algorithm Analysis and Problem Complexity
出版者:Springer Berlin / Heidelberg
ISSN:1611-3349
文摘
Bivalent promoters are defined by the presence of both activating (H3K4me3) and repressive (H3K27me3) chromatin marks. In this paper, we first identified high confidence bivalent promoters in murine ES cells integrating data across eight studies using two methods; peak-based and cutoff-based. We showed that peak-based method is more reliable as promoters are more enriched for developmental regulators than the cutoff-based method. We further identified bivalent promoters in human and pig using the peak-based method to show that the bivalent promoters conserved across species were highly enriched for embryonic developmental processes.