A hybrid PDMS-Parylene subdural multi-electrode array

详细信息    查看全文

• 作者：Manuel Ochoa (1) (4)
  Pinghung Wei (1) (4)
  Andrew J. Wolley (2)
  Kevin J. Otto (2) (3)
  Babak Ziaie (1) (3) (4)
  
• 关键词：PDMS ; Parylene ; Epilepsy ; Brain Computer Interface (BCI) ; Subdural electrode ; ECoG ; Flexible electrode
• 刊名：Biomedical Microdevices
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：15
• 期：3
• 页码：437-443
• 全文大小：639KB
• 参考文献：1. A-D Tech Medical Instruments, Intraoperative Monitoring Subdural Strip Electrodes, http://www.adtechmedical.com/intraoperative-monitoring-subdural-strip-electrodes/. Accessed 18 Jul 2012
  2. D. Armani, C. Liu, N. Aluru, in / Twelfth IEEE International Conference on Micro Electro Mechanical Systems (1999)
  3. S.F. Cogan, Annu. Rev. Biomed. Eng. 10, (2008)
  4. DuPont, General Specifications for Kapton? Polyimide Films, http://www2.dupont.com/Kapton/en_US/assets/downloads/pdf/summaryofprop.pdf. Accessed 18 Jul 2012
  5. D.T. Eddington, D.J. Beebe, Biomed. Microdevices 7, 3 (2005) CrossRef
  6. C. Feger, Polym. Eng. Sci. 29, 5 (1989) CrossRef
  7. B. Graimann, J.E. Huggins, S.P. Levine, G. Pfurtscheller, IEEE Trans. Biomed. Eng. 51, 6 (2004) CrossRef
  8. C. Henle, M. Raab, J.G. Cordeiro, S. Doostkam, A. Schulze-Bonhage, T. Stieglitz, J. Rickert, Biomed. Microdevices 13, 1 (2011) CrossRef
  9. D.-H. Kim, J. Viventi, J.J. Amsden, J. Xiao, L. Vigeland, Y.-S. Kim, J.A. Blanco, B. Panilaitis, E.S. Frechette, D. Contreras, D.L. Kaplan, F.G. Omenetto, Y. Huang, K.-C. Hwang, M.R. Zakin, B. Litt, J.A. Rogers, Nat. Mater. 9, 6 (2010) CrossRef
  10. K. Ludwig, J.D. Uram, J. Yang, D.C. Martin, D.R. Kipke, J. Neural Eng. 3, 1 (2006) CrossRef
  11. L.I. Maissel, R. Glang, / Handbook of Thin Film Technology, (McGraw-Hill, 1970)
  12. E.M. Maynard, E. Fernandez, R. Normann, J. Neurosci. Methods 97, 2 (2000) CrossRef
  13. D.R. Nair, R. Burgess, C.C. McIntyre, H. Lüders, Clin. Neurophysiol. 119, 1 (2008) CrossRef
  14. G.A. Ojemann, Annu. Rev. Med. 48, (1997)
  15. D.C. Rodger, Y.C. Tai, IEEE Engineering in Medicine and Biology Magazine 24, 5 (2005)
  16. P.J. Rousche, D.S. Pellinen, D.P. Pivin, J.C. Williams, R.J. Vetter, D.R. Kipke, IEEE Trans. Biomed. Eng. 48, 3 (2001) CrossRef
  17. B. Rubehn, C. Bosman, R. Oostenveld, P. Fries, T. Stieglitz, J. Neural Eng. 6, 3 (2009) CrossRef
  18. Specialty Coating Systems, SCS Parylene Properties, http://scscoatings.com/docs/brochures/parylene_properties.pdf. Accessed18 Jul 2012
  19. H. Toda, T. Suzuki, H. Sawahata, K. Majima, Y. Kamitani, I. Hasegawa, NeuroImage 54, 1 (2011) CrossRef
  20. C.H. Wong, J. Birkett, K. Byth, M. Dexter, E. Somerville, D. Gill, R. Chaseling, M. Fearnside, A. Bleasel, Acta Neurochir. (Wien) 151, 1 (2009) CrossRef
  21. J.D. Yeager, D.J. Phillips, D.M. Rector, D.F. Bahr, J. Neurosci. Methods 173, 2 (2008) CrossRef
  
• 作者单位：Manuel Ochoa (1) (4)
  Pinghung Wei (1) (4)
  Andrew J. Wolley (2)
  Kevin J. Otto (2) (3)
  Babak Ziaie (1) (3) (4)
  
  1. School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA
  4. Birck Nanotechnology Center, Purdue University, West Lafayette, IN, 47907, USA
  2. Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA
  3. Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA
  
• ISSN：1572-8781

文摘

In this paper, we report on a cost effective and simple method for fabricating a flexible multi-electrode array for subdural neural recording. The electrode was fabricated using a PDMS-Parylene bilayer to combine the major advantages of both materials. Mechanical and electrical characterizations were performed to confirm functionality of a 16-site electrode array under various flexed/bent conditions. The electrode array was helically wound around a 3?mm diameter cylindrical tube and laid over a 2?cm diameter sphere while maintaining its recording capability. Experimental results showed impedance values between 300?kΩ and 600?kΩ at 1?kHz for 90?μm diameter gold recording sites. Acoustically evoked neural activity was successfully recorded from rat auditory cortex, confirming in vivo functionality.