Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health

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• 作者：Marcus Altfeld ; Madeleine J. Bunders
• 关键词：HIV ; 1 ; MTCT ; Immune activation ; Pregnancy ; Infant
• 刊名：Springer Seminars in Immunopathology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：38
• 期：6
• 页码：727-738
• 全文大小：617 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Immunology
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1863-2300
• 卷排序：38

文摘

Adaptation of the maternal immune system to establish maternal/fetal equilibrium is required for a successful pregnancy. Viral infections, including HIV-1 infection, can alter this maternal/fetal equilibrium, with significant consequences for pregnancy outcome, including miscarriages, impaired fetal growth, and premature delivery. Furthermore, maternal HIV-1 infection has been shown to have a long-term impact on the developing fetal immune system also when the infant is not infected with the virus. In this review, we discuss the consequences of maternal HIV-1 infection and antiretroviral therapy on pregnancy outcome and the health of the uninfected HIV-1-exposed infant.