2MD, a new anabolic agent for osteoporosis treatment

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• 作者：Lori A. Plum ; Lorraine A. Fitzpatrick ; Xiaohong Ma ; Neil C. Binkley ; Julia B. Zella ; Margaret Clagett-Dame and Hector F. DeLuca
• 关键词：Vitamin D analog ; Osteoporosis ; Rat ; Bone ; Therapy
• 刊名：Osteoporosis International
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：17
• 期：5
• 页码：704-715
• 全文大小：451 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Orthopedics
  Gynecology
  Endocrinology
  Rheumatology
  
• 出版者：Springer London
• ISSN：1433-2965

文摘

Introduction 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D₃ (2MD) is a new analog of 1α,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃) that has unique properties (distinct from 1α,25-dihydroxyvitamin D₃) in stimulating osteoblasts to form bone in culture. This analog has now been extensively tested in aged ovariectomized female rats maintained on a diet adequate in calcium and phosphorus.