Aquaporin-5: from structure to function and dysfunction in cancer
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- 作者：Inês Direito ; Ana Madeira ; Maria Alexandra Brito…
- 关键词：Aquaporin ; Biomarker ; Tumor ; Signaling pathways ; Water channel ; Permeability
- 刊名：Cellular and Molecular Life Sciences (CMLS)
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：73
- 期：8
- 页码：1623-1640
- 全文大小：2,163 KB
- 参考文献：1.Paganelli CV, Solomon AK (1957) The rate of exchange of tritiated water across the human red cell membrane. J Gen Physiol 41(2):259–277PubMed PubMedCentral CrossRef
2.Whittembury G (1960) Ion and water transport in the proximal tubules of the kidney of Necturus maculosus. J Gen Physiol 43:43–56PubMed PubMedCentral CrossRef
3.Smith BL, Agre P (1991) Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins. J Biol Chem 266(10):6407–6415PubMed
4.Agre P, Saboori AM, Asimos A, Smith BL (1987) Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. J Biol Chem 262(36):17497–17503PubMed
5.Preston GM, Agre P (1991) Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family. Proc Natl Acad Sci USA 88(24):11110–11114PubMed PubMedCentral CrossRef
6.Zeidel ML, Ambudkar SV, Smith BL, Agre P (1992) Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 31(33):7436–7440PubMed CrossRef
7.Preston GM, Carroll TP, Guggino WB, Agre P (1992) Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256(5055):385–387PubMed CrossRef
8.Abascal F, Irisarri I, Zardoya R (2014) Diversity and evolution of membrane intrinsic proteins. Biochim Biophys Acta 1840(5):1468–1481. doi:10.1016/j.bbagen.2013.12.001 PubMed CrossRef
9.Noda Y, Sohara E, Ohta E, Sasaki S (2010) Aquaporins in kidney pathophysiology. Nat Rev Nephrol 6(3):168–178. doi:10.1038/nrneph.2009.231 PubMed CrossRef
10.Papadopoulos MC, Verkman AS (2013) Aquaporin water channels in the nervous system. Nat Rev Neurosci 14(4):265–277. doi:10.1038/nrn3468 PubMed PubMedCentral CrossRef
11.Saadoun S, Papadopoulos MC, Hara-Chikuma M, Verkman AS (2005) Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature 434(7034):786–792. doi:10.1038/nature03460 PubMed CrossRef
12.Hiroaki Y, Tani K, Kamegawa A, Gyobu N, Nishikawa K, Suzuki H, Walz T, Sasaki S, Mitsuoka K, Kimura K, Mizoguchi A, Fujiyoshi Y (2006) Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol 355(4):628–639. doi:10.1016/j.jmb.2005.10.081 PubMed CrossRef
13.Hara-Chikuma M, Verkman AS (2008) Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing. J Mol Med (Berl) 86(2):221–231. doi:10.1007/s00109-007-0272-4 CrossRef
14.Serna A, Galan-Cobo A, Rodrigues C, Sanchez-Gomar I, Toledo-Aral JJ, Moura TF, Casini A, Soveral G, Echevarria M (2014) Functional inhibition of aquaporin-3 with a gold-based compound induces blockage of cell proliferation. J Cell Physiol 229(11):1787–1801. doi:10.1002/jcp.24632 PubMed CrossRef
15.Madeira A, Mosca AF, Moura TF, Soveral G (2015) Aquaporin-5 is expressed in adipocytes with implications in adipose differentiation. IUBMB Life 67(1):54–60. doi:10.1002/iub.1345 PubMed CrossRef
16.Verkman AS, Anderson MO, Papadopoulos MC (2014) Aquaporins: important but elusive drug targets. Nat Rev Drug Discov 13(4):259–277. doi:10.1038/nrd4226 PubMed PubMedCentral CrossRef
17.Murata K, Mitsuoka K, Hirai T, Walz T, Agre P, Heymann JB, Engel A, Fujiyoshi Y (2000) Structural determinants of water permeation through aquaporin-1. Nature 407(6804):599–605. doi:10.1038/35036519 PubMed CrossRef
18.Ma T, Yang B, Verkman AS (1997) Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun 240(2):324–328. doi:10.1006/bbrc.1997.7664 PubMed CrossRef
19.Bienert GP, Moller AL, Kristiansen KA, Schulz A, Moller IM, Schjoerring JK, Jahn TP (2007) Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem 282(2):1183–1192. doi:10.1074/jbc.M603761200 PubMed CrossRef
20.Holm LM, Jahn TP, Moller AL, Schjoerring JK, Ferri D, Klaerke DA, Zeuthen T (2005) NH3 and NH4 + permeability in aquaporin-expressing Xenopus oocytes. Pflugers Arch 450(6):415–428. doi:10.1007/s00424-005-1399-1 PubMed CrossRef
21.Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (2002) Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63. J Biol Chem 277(42):39873–39879. doi:10.1074/jbc.M207008200 PubMed CrossRef
22.Sanders OI, Rensing C, Kuroda M, Mitra B, Rosen BP (1997) Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli. J Bacteriol 179(10):3365–3367PubMed PubMedCentral
23.Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P, Rosen BP (2002) Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci USA 99(9):6053–6058. doi:10.1073/pnas.092131899 PubMed PubMedCentral CrossRef
24.Herrera M, Hong NJ, Garvin JL (2006) Aquaporin-1 transports NO across cell membranes. Hypertension 48(1):157–164. doi:10.1161/01.HYP.0000223652.29338.77 PubMed CrossRef
25.Ma JF, Tamai K, Yamaji N, Mitani N, Konishi S, Katsuhara M, Ishiguro M, Murata Y, Yano M (2006) A silicon transporter in rice. Nature 440(7084):688–691. doi:10.1038/nature04590 PubMed CrossRef
26.Nakhoul NL, Davis BA, Romero MF, Boron WF (1998) Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes. Am J Physiol 274(2 Pt 1):C543–C548PubMed
27.Yasui M, Hazama A, Kwon TH, Nielsen S, Guggino WB, Agre P (1999) Rapid gating and anion permeability of an intracellular aquaporin. Nature 402(6758):184–187. doi:10.1038/46045 PubMed CrossRef
28.Rojek A, Praetorius J, Frokiaer J, Nielsen S, Fenton RA (2008) A current view of the mammalian aquaglyceroporins. Annu Rev Physiol 70:301–327. doi:10.1146/annurev.physiol.70.113006.100452 PubMed CrossRef
29.Benga G (2012) On the definition, nomenclature and classification of water channel proteins (aquaporins and relatives). Mol Aspects Med 33(5–6):514–517. doi:10.1016/j.mam.2012.04.003 PubMed CrossRef
30.Ishibashi K, Tanaka Y, Morishita Y (2014) The role of mammalian superaquaporins inside the cell. Biochim Biophys Acta 1840(5):1507–1512. doi:10.1016/j.bbagen.2013.10.039 PubMed CrossRef
31.Yakata K, Tani K, Fujiyoshi Y (2011) Water permeability and characterization of aquaporin-11. J Struct Biol 174(2):315–320. doi:10.1016/j.jsb.2011.01.003 PubMed CrossRef
32.Madeira A, Fernandez-Veledo S, Camps M, Zorzano A, Moura TF, Ceperuelo-Mallafre V, Vendrell J, Soveral G (2014) Human aquaporin-11 is a water and glycerol channel and localizes in the vicinity of lipid droplets in human adipocytes. Obesity (Silver Spring) 22(9):2010–2017. doi:10.1002/oby.20792 CrossRef
33.Videira M, Reis RL, Brito MA (2014) Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance. Biochim Biophys Acta 1846(2):312–325. doi:10.1016/j.bbcan.2014.07.011 PubMed
34.Verkman AS, Hara-Chikuma M, Papadopoulos MC (2008) Aquaporins–new players in cancer biology. J Mol Med (Berl) 86(5):523–529. doi:10.1007/s00109-008-0303-9 CrossRef
35.Papadopoulos MC, Saadoun S (2015) Key roles of aquaporins in tumor biology. Biochim Biophys Acta 1848(10 Pt B):2576–2583. doi:10.1016/j.bbamem.2014.09.001 PubMed CrossRef
36.Miller EW, Dickinson BC, Chang CJ (2010) Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci USA 107(36):15681–15686. doi:10.1073/pnas.1005776107 PubMed PubMedCentral CrossRef
37.Cordeiro RM (2015) Molecular dynamics simulations of the transport of reactive oxygen species by mammalian and plant aquaporins. Biochim Biophys Acta 1850(9):1786–1794. doi:10.1016/j.bbagen.2015.05.007 PubMed CrossRef
38.Liou GY, Storz P (2010) Reactive oxygen species in cancer. Free Radic Res 44(5):479–496. doi:10.3109/10715761003667554 PubMed CrossRef
39.Guo X, Sun T, Yang M, Li Z, Li Z, Gao Y (2013) Prognostic value of combined aquaporin 3 and aquaporin 5 overexpression in hepatocellular carcinoma. Biomed Res Int 2013:206525. doi:10.1155/2013/206525 PubMed PubMedCentral
40.Lee SJ, Chae YS, Kim JG, Kim WW, Jung JH, Park HY, Jeong JY, Park JY, Jung HJ, Kwon TH (2014) AQP5 expression predicts survival in patients with early breast cancer. Ann Surg Oncol 21(2):375–383. doi:10.1245/s10434-013-3317-7 PubMed CrossRef
41.Shan T, Cui X, Li W, Lin W, Li Y (2014) AQP5: a novel biomarker that predicts poor clinical outcome in colorectal cancer. Oncol Rep 32(4):1564–1570. doi:10.3892/or.2014.3377 PubMed
42.Kang BW, Kim JG, Lee SJ, Chae YS, Jeong JY, Yoon GS, Park SY, Kim HJ, Park JS, Choi GS, Jeong JY (2015) Expression of aquaporin-1, aquaporin-3, and aquaporin-5 correlates with nodal metastasis in colon cancer. Oncology 88(6):369–376. doi:10.1159/000369073 PubMed CrossRef
43.Raina S, Preston GM, Guggino WB, Agre P (1995) Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues. J Biol Chem 270(4):1908–1912PubMed CrossRef
44.Matsuzaki T, Tajika Y, Ablimit A, Aoki T, Hagiwara H, Takata K (2004) Aquaporins in the digestive system. Med Electron Microsc 37(2):71–80. doi:10.1007/s00795-004-0246-3 PubMed CrossRef
45.Delporte C (2014) Aquaporins in salivary glands and pancreas. Biochim Biophys Acta 1840(5):1524–1532. doi:10.1016/j.bbagen.2013.08.007 PubMed CrossRef
46.Procino G, Mastrofrancesco L, Sallustio F, Costantino V, Barbieri C, Pisani F, Schena FP, Svelto M, Valenti G (2011) AQP5 is expressed in type-B intercalated cells in the collecting duct system of the rat, mouse and human kidney. Cell Physiol Biochem 28(4):683–692. doi:10.1159/000335762 PubMed CrossRef
47.Kreda SM, Gynn MC, Fenstermacher DA, Boucher RC, Gabriel SE (2001) Expression and localization of epithelial aquaporins in the adult human lung. Am J Respir Cell Mol Biol 24(3):224–234. doi:10.1165/ajrcmb.24.3.4367 PubMed CrossRef
48.Wang K, Feng YL, Wen FQ, Chen XR, Ou XM, Xu D, Yang J, Deng ZP (2007) Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease. Acta Pharmacol Sin 28(8):1166–1174. doi:10.1111/j.1745-7254.2007.00608.x PubMed CrossRef
49.Seno S, Ogawa T, Shibayama M, Kouzaki H, Shimizu T (2012) Expression and localization of aquaporin 1, 2, 3, 4, and 5 in human nasal mucosa. Am J Rhinol Allergy 26(3):167–171. doi:10.2500/ajra.2012.26.3742 PubMed CrossRef
50.Iizuka T, Suzuki T, Nakano K, Sueki H (2012) Immunolocalization of aquaporin-5 in normal human skin and hypohidrotic skin diseases. J Dermatol 39(4):344–349. doi:10.1111/j.1346-8138.2011.01327.x PubMed CrossRef
51.Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S (2013) Immunolocalization and translocation of aquaporin-5 water channel in sweat glands. J Dermatol Sci 70(1):26–33. doi:10.1016/j.jdermsci.2013.01.013 PubMed CrossRef
52.Cao X, Yin J, Wang H, Zhao J, Zhang J, Dai L, Zhang J, Jiang H, Lin Z, Yang Y (2014) Mutation in AQP5, encoding aquaporin 5, causes palmoplantar keratoderma Bothnia type. J Invest Dermatol 134(1):284–287. doi:10.1038/jid.2013.302 PubMed CrossRef
53.Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJ, Wilson NJ, McLean WH, Munro CS, South AP, Leigh IM, O’Toole EA, Lundstrom A, Kelsell DP (2013) Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet 93(2):330–335. doi:10.1016/j.ajhg.2013.06.008 PubMed PubMedCentral CrossRef
54.Kim SO, Oh KJ, Lee HS, Ahn K, Kim SW, Park K (2011) Expression of aquaporin water channels in the vagina in premenopausal women. J Sex Med 8(7):1925–1930. doi:10.1111/j.1743-6109.2011.02284.x PubMed CrossRef
55.Skowronski MT, Frackowiak L, Skowronska A (2012) The expression of aquaporin 1 and 5 in uterine leiomyomata in premenopausal women: a preliminary study. Reprod Biol 12(1):81–89PubMed CrossRef
56.Kenney MC, Atilano SR, Zorapapel N, Holguin B, Gaster RN, Ljubimov AV (2004) Altered expression of aquaporins in bullous keratopathy and Fuchs’ dystrophy corneas. J Histochem Cytochem 52(10):1341–1350. doi:10.1369/jhc.4A6385.2004 PubMed CrossRef
57.Garfias Y, Navas A, Perez-Cano HJ, Quevedo J, Villalvazo L, Zenteno JC (2008) Comparative expression analysis of aquaporin-5 (AQP5) in keratoconic and healthy corneas. Mol Vis 14:756–761PubMed PubMedCentral
58.Hirt B, Penkova ZH, Eckhard A, Liu W, Rask-Andersen H, Muller M, Lowenheim H (2010) The subcellular distribution of aquaporin 5 in the cochlea reveals a water shunt at the perilymph-endolymph barrier. Neuroscience 168(4):957–970. doi:10.1016/j.neuroscience.2009.09.002 PubMed CrossRef
59.Shankardas J, Patil RV, Vishwanatha JK (2010) Effect of down-regulation of aquaporins in human corneal endothelial and epithelial cell lines. Mol Vis 16:1538–1548PubMed PubMedCentral
60.Grey AC, Walker KL, Petrova RS, Han J, Wilmarth PA, David LL, Donaldson PJ, Schey KL (2013) Verification and spatial localization of aquaporin-5 in the ocular lens. Exp Eye Res 108:94–102. doi:10.1016/j.exer.2012.12.004 PubMed PubMedCentral CrossRef
61.Burghardt B, Elkaer ML, Kwon TH, Racz GZ, Varga G, Steward MC, Nielsen S (2003) Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut 52(7):1008–1016PubMed PubMedCentral CrossRef
62.Kouznetsova I, Gerlach KL, Zahl C, Hoffmann W (2010) Expression analysis of human salivary glands by laser microdissection: differences between submandibular and labial glands. Cell Physiol Biochem 26(3):375–382. doi:10.1159/000320561 PubMed CrossRef
63.Gresz V, Kwon TH, Hurley PT, Varga G, Zelles T, Nielsen S, Case RM, Steward MC (2001) Identification and localization of aquaporin water channels in human salivary glands. Am J Physiol Gastrointest Liver Physiol 281(1):G247–G254PubMed
64.Collaco AM, Jakab RL, Hoekstra NE, Mitchell KA, Brooks A, Ameen NA (2013) Regulated traffic of anion transporters in mammalian Brunner’s glands: a role for water and fluid transport. Am J Physiol Gastrointest Liver Physiol 305(3):G258–G275. doi:10.1152/ajpgi.00485.2012 PubMed PubMedCentral CrossRef
65.Jiang XX, Wu RJ, Xu KH, Zhou CY, Guo XY, Sun YL, Lin J (2010) Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas. Fertil Steril 94(4):1229–1234. doi:10.1016/j.fertnstert.2009.08.053 PubMed CrossRef
66.Tsubota K, Hirai S, King LS, Agre P, Ishida N (2001) Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjogren’s syndrome. Lancet 357(9257):688–689. doi:10.1016/S0140-6736(00)04140-4 PubMed CrossRef
67.Jung HJ, Park JY, Jeon HS, Kwon TH (2011) Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cells. PLoS One 6(12):e28492. doi:10.1371/journal.pone.0028492 PubMed PubMedCentral CrossRef
68.McManaman JL, Reyland ME, Thrower EC (2006) Secretion and fluid transport mechanisms in the mammary gland: comparisons with the exocrine pancreas and the salivary gland. J Mammary Gland Biol Neoplasia 11(3–4):249–268. doi:10.1007/s10911-006-9031-3 PubMed CrossRef
69.Horsefield R, Norden K, Fellert M, Backmark A, Tornroth-Horsefield S, Terwisscha van Scheltinga AC, Kvassman J, Kjellbom P, Johanson U, Neutze R (2008) High-resolution X-ray structure of human aquaporin 5. Proc Natl Acad Sci USA 105(36):13327–13332. doi:10.1073/pnas.0801466105 PubMed PubMedCentral CrossRef
70.Hub JS, Grubmuller H, de Groot BL (2009) Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations? Handb Exp Pharmacol 190:57–76. doi:10.1007/978-3-540-79885-9_3 PubMed CrossRef
71.Wang Y, Tajkhorshid E (2010) Nitric oxide conduction by the brain aquaporin AQP4. Proteins 78(3):661–670. doi:10.1002/prot.22595 PubMed PubMedCentral
72.Yool AJ, Weinstein AM (2002) New roles for old holes: ion channel function in aquaporin-1. News Physiol Sci 17:68–72PubMed
73.Boassa D, Stamer WD, Yool AJ (2006) Ion channel function of aquaporin-1 natively expressed in choroid plexus. J Neurosci 26(30):7811–7819. doi:10.1523/JNEUROSCI.0525-06.2006 PubMed CrossRef
74.Zhang YB, Chen LY (2013) In silico study of aquaporin V: effects and affinity of the central pore-occluding lipid. Biophys Chem 171:24–30. doi:10.1016/j.bpc.2012.09.004 PubMed PubMedCentral CrossRef
75.Tani K, Fujiyoshi Y (2014) Water channel structures analysed by electron crystallography. Biochim Biophys Acta 1840(5):1605–1613. doi:10.1016/j.bbagen.2013.10.007 PubMed CrossRef
76.Preston GM, Jung JS, Guggino WB, Agre P (1994) Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. J Biol Chem 269(3):1668–1673PubMed
77.Kozono D, Yasui M, King LS, Agre P (2002) Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine. J Clin Investig 109(11):1395–1399. doi:10.1172/JCI15851 PubMed PubMedCentral CrossRef
78.de Groot BL, Grubmuller H (2001) Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. Science 294(5550):2353–2357. doi:10.1126/science.1062459 PubMed CrossRef
79.Soveral G, Prista C, Moura TF, Loureiro-Dias MC (2010) Yeast water channels: an overview of orthodox aquaporins. Biol Cell 103(1):35–54. doi:10.1042/BC20100102 PubMed CrossRef
80.Kosinska Eriksson U, Fischer G, Friemann R, Enkavi G, Tajkhorshid E, Neutze R (2013) Subangstrom resolution X-ray structure details aquaporin-water interactions. Science 340(6138):1346–1349. doi:10.1126/science.1234306 PubMed CrossRef
81.Yao C, Purwanti N, Karabasil MR, Azlina A, Javkhlan P, Hasegawa T, Akamatsu T, Hosoi T, Ozawa K, Hosoi K (2010) Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-kappaB and p-c-Jun/c-Fos. Am J Pathol 177(2):724–734. doi:10.2353/ajpath.2010.090282 PubMed PubMedCentral CrossRef
82.Borok Z, Li X, Fernandes VF, Zhou B, Ann DK, Crandall ED (2000) Differential regulation of rat aquaporin-5 promoter/enhancer activities in lung and salivary epithelial cells. J Biol Chem 275(34):26507–26514. doi:10.1074/jbc.M910007199 PubMed CrossRef
83.Kobayashi M, Takahashi E, Miyagawa S, Watanabe H, Iguchi T (2006) Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus. Genes Cells 11(10):1133–1143. doi:10.1111/j.1365-2443.2006.01009.x PubMed CrossRef
84.Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z (2008) GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol 295(5):C1141–C1150. doi:10.1152/ajpcell.00120.2008 PubMed PubMedCentral CrossRef
85.Guo K, Jin F (2015) NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression. Biochem Biophys Res Commun 465(3):644–649. doi:10.1016/j.bbrc.2015.08.078 PubMed CrossRef
86.Hollborn M, Vogler S, Reichenbach A, Wiedemann P, Bringmann A, Kohen L (2015) Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Mol Vis 21:360–377PubMed PubMedCentral
87.Kawedia JD, Yang F, Sartor MA, Gozal D, Czyzyk-Krzeska M, Menon AG (2013) Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1alpha and proteasome-mediated pathways. PLoS One 8(3):e57541. doi:10.1371/journal.pone.0057541 PubMed PubMedCentral CrossRef
88.Ishikawa Y, Cho G, Yuan Z, Inoue N, Nakae Y (2006) Aquaporin-5 water channel in lipid rafts of rat parotid glands. Biochim Biophys Acta 1758(8):1053–1060. doi:10.1016/j.bbamem.2006.03.026 PubMed CrossRef
89.Yang F, Kawedia JD, Menon AG (2003) Cyclic AMP regulates aquaporin 5 expression at both transcriptional and post-transcriptional levels through a protein kinase A pathway. J Biol Chem 278(34):32173–32180. doi:10.1074/jbc.M305149200 PubMed CrossRef
90.Sidhaye V, Hoffert JD, King LS (2005) cAMP has distinct acute and chronic effects on aquaporin-5 in lung epithelial cells. J Biol Chem 280(5):3590–3596. doi:10.1074/jbc.M411038200 PubMed CrossRef
91.Woo J, Chae YK, Jang SJ, Kim MS, Baek JH, Park JC, Trink B, Ratovitski E, Lee T, Park B, Park M, Kang JH, Soria JC, Lee J, Califano J, Sidransky D, Moon C (2008) Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun 366(2):321–327. doi:10.1016/j.bbrc.2007.11.078 PubMed CrossRef
92.Woo J, Lee J, Kim MS, Jang SJ, Sidransky D, Moon C (2008) The effect of aquaporin 5 overexpression on the Ras signaling pathway. Biochem Biophys Res Commun 367(2):291–298. doi:10.1016/j.bbrc.2007.12.073 PubMed CrossRef
93.Woo J, Lee J, Chae YK, Kim MS, Baek JH, Park JC, Park MJ, Smith IM, Trink B, Ratovitski E, Lee T, Park B, Jang SJ, Soria JC, Califano JA, Sidransky D, Moon C (2008) Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett 264(1):54–62. doi:10.1016/j.canlet.2008.01.029 PubMed PubMedCentral CrossRef
94.Kitchen P, Oberg F, Sjohamn J, Hedfalk K, Bill RM, Conner AC, Conner MT, Tornroth-Horsefield S (2015) Plasma membrane abundance of human aquaporin 5 is dynamically regulated by multiple pathways. PLoS One 10(11):e0143027. doi:10.1371/journal.pone.0143027 PubMed PubMedCentral CrossRef
95.Tornroth-Horsefield S, Hedfalk K, Fischer G, Lindkvist-Petersson K, Neutze R (2010) Structural insights into eukaryotic aquaporin regulation. FEBS Lett 584(12):2580–2588. doi:10.1016/j.febslet.2010.04.037 PubMed CrossRef
96.Janosi L, Ceccarelli M (2013) The gating mechanism of the human aquaporin 5 revealed by molecular dynamics simulations. PLoS One 8(4):e59897. doi:10.1371/journal.pone.0059897 PubMed PubMedCentral CrossRef
97.Delporte C (2009) Aquaporins in secretory glands and their role in Sjogren’s syndrome. Handb Exp Pharmacol 190:185–201. doi:10.1007/978-3-540-79885-9_9 PubMed CrossRef
98.Ma T, Song Y, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (1999) Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels. J Biol Chem 274(29):20071–20074PubMed CrossRef
99.Song Y, Verkman AS (2001) Aquaporin-5 dependent fluid secretion in airway submucosal glands. J Biol Chem 276(44):41288–41292. doi:10.1074/jbc.M107257200 PubMed CrossRef
100.Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS (2000) Lung fluid transport in aquaporin-5 knockout mice. J Clin Investig 105(1):93–100. doi:10.1172/JCI8258 PubMed PubMedCentral CrossRef
101.Thiagarajah JR, Verkman AS (2002) Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling. J Biol Chem 277(21):19139–19144. doi:10.1074/jbc.M202071200 PubMed CrossRef
102.Chae YK, Woo J, Kim MJ, Kang SK, Kim MS, Lee J, Lee SK, Gong G, Kim YH, Soria JC, Jang SJ, Sidransky D, Moon C (2008) Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS One 3(5):e2162. doi:10.1371/journal.pone.0002162 PubMed PubMedCentral CrossRef
103.Kang SK, Chae YK, Woo J, Kim MS, Park JC, Lee J, Soria JC, Jang SJ, Sidransky D, Moon C (2008) Role of human aquaporin 5 in colorectal carcinogenesis. Am J Pathol 173(2):518–525. doi:10.2353/ajpath.2008.071198 PubMed PubMedCentral CrossRef
104.Ishimoto S, Wada K, Usami Y, Tanaka N, Aikawa T, Okura M, Nakajima A, Kogo M, Kamisaki Y (2012) Differential expression of aquaporin 5 and aquaporin 3 in squamous cell carcinoma and adenoid cystic carcinoma. Int J Oncol 41(1):67–75. doi:10.3892/ijo.2012.1445 PubMed
105.Shi X, Wu S, Yang Y, Tang L, Wang Y, Dong J, Lu B, Jiang G, Zhao W (2014) AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells. Tumour Biol 35(7):7035–7045. doi:10.1007/s13277-014-1956-3 PubMed CrossRef
106.Li J, Wang Z, Chong T, Chen H, Li H, Li G, Zhai X, Li Y (2014) Over-expression of a poor prognostic marker in prostate cancer: AQP5 promotes cells growth and local invasion. World J Surg Oncol 12:284. doi:10.1186/1477-7819-12-284 PubMed PubMedCentral CrossRef
107.Chae YK, Kang SK, Kim MS, Woo J, Lee J, Chang S, Kim DW, Kim M, Park S, Kim I, Keam B, Rhee J, Koo NH, Park G, Kim SH, Jang SE, Kweon IY, Sidransky D, Moon C (2008) Human AQP5 plays a role in the progression of chronic myelogenous leukemia (CML). PLoS One 3(7):e2594. doi:10.1371/journal.pone.0002594 PubMed PubMedCentral CrossRef
108.Yan C, Zhu Y, Zhang X, Chen X, Zheng W, Yang J (2014) Down-regulated aquaporin 5 inhibits proliferation and migration of human epithelial ovarian cancer 3AO cells. J Ovarian Res 7:78. doi:10.1186/s13048-014-0078-2 PubMed PubMedCentral CrossRef
109.Yan C, Yang J, Shen L, Chen X (2012) Inhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression. Arch Gynecol Obstet 285(2):459–467. doi:10.1007/s00404-011-1942-6 PubMed CrossRef
110.Yang J, Yan C, Zheng W, Chen X (2012) Proliferation inhibition of cisplatin and aquaporin 5 expression in human ovarian cancer cell CAOV3. Arch Gynecol Obstet 285(1):239–245. doi:10.1007/s00404-011-1908-8 PubMed CrossRef
111.Zhang Z, Chen Z, Song Y, Zhang P, Hu J, Bai C (2010) Expression of aquaporin 5 increases proliferation and metastasis potential of lung cancer. J Pathol 221(2):210–220. doi:10.1002/path.2702 PubMed CrossRef
112.Huang YH, Zhou XY, Wang HM, Xu H, Chen J, Lv NH (2013) Aquaporin 5 promotes the proliferation and migration of human gastric carcinoma cells. Tumour Biol 34(3):1743–1751. doi:10.1007/s13277-013-0712-4 PubMed CrossRef
113.Jiang XX, Xu KH, Ma JY, Tian YH, Guo XY, Lin J, Wu RJ (2012) Reduced migration of Ishikawa cells associated with downregulation of aquaporin-5. Oncol Lett 4(2):257–261. doi:10.3892/ol.2012.738 PubMed PubMedCentral
114.Moon C, Soria JC, Jang SJ, Lee J, Obaidul Hoque M, Sibony M, Trink B, Chang YS, Sidransky D, Mao L (2003) Involvement of aquaporins in colorectal carcinogenesis. Oncogene 22(43):6699–6703. doi:10.1038/sj.onc.1206762 PubMed CrossRef
115.Wang W, Li Q, Yang T, Bai G, Li D, Li Q, Sun H (2012) Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance. World J Surg Oncol 10:242. doi:10.1186/1477-7819-10-242 PubMed PubMedCentral CrossRef
116.Zhang ZQ, Zhu ZX, Bai CX (2012) Lung fluorescence imaging to evaluate tumor metastasis induced by AQP5 expression in murine model. Med Oncol 29(1):205–211. doi:10.1007/s12032-010-9788-5 PubMed CrossRef
117.Zhang ZQ, Zhu ZX, Bai CX, Chen ZH (2011) Aquaporin 5 expression increases mucin production in lung adenocarcinoma. Oncol Rep 25(6):1645–1650. doi:10.3892/or.2011.1241 PubMed
118.Machida Y, Ueda Y, Shimasaki M, Sato K, Sagawa M, Katsuda S, Sakuma T (2011) Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Hum Pathol 42(5):669–678. doi:10.1016/j.humpath.2010.07.022 PubMed CrossRef
119.Chen Z, Zhang Z, Gu Y, Bai C (2011) Impaired migration and cell volume regulation in aquaporin 5-deficient SPC-A1 cells. Respir Physiol Neurobiol 176(3):110–117. doi:10.1016/j.resp.2011.02.001 PubMed CrossRef
120.Shi Z, Zhang T, Luo L, Zhao H, Cheng J, Xiang J, Zhao C (2012) Aquaporins in human breast cancer: identification and involvement in carcinogenesis of breast cancer. J Surg Oncol 106(3):267–272. doi:10.1002/jso.22155 PubMed CrossRef
121.Yang JH, Shi YF, Cheng Q, Deng L (2006) Expression and localization of aquaporin-5 in the epithelial ovarian tumors. Gynecol Oncol 100(2):294–299. doi:10.1016/j.ygyno.2005.08.054 PubMed CrossRef
122.Yang JH, Yu YQ, Yan CX (2011) Localisation and expression of aquaporin subtypes in epithelial ovarian tumours. Histol Histopathol 26(9):1197–1205PubMed
123.Zhang T, Zhao C, Chen D, Zhou Z (2012) Overexpression of AQP5 in cervical cancer: correlation with clinicopathological features and prognosis. Med Oncol 29(3):1998–2004. doi:10.1007/s12032-011-0095-6 PubMed CrossRef
124.Shimizu H, Shiozaki A, Ichikawa D, Fujiwara H, Konishi H, Ishii H, Komatsu S, Kubota T, Okamoto K, Kishimoto M, Otsuji E (2014) The expression and role of aquaporin 5 in esophageal squamous cell carcinoma. J Gastroenterol 49(4):655–666. doi:10.1007/s00535-013-0827-9 PubMed CrossRef
125.Liu S, Zhang S, Jiang H, Yang Y, Jiang Y (2013) Co-expression of AQP3 and AQP5 in esophageal squamous cell carcinoma correlates with aggressive tumor progression and poor prognosis. Med Oncol 30(3):636. doi:10.1007/s12032-013-0636-2 PubMed CrossRef
126.Lambertz N, Hindy NE, Adler C, Rump K, Adamzik M, Keyvani K, Bankfalvi A, Siffert W, Erol Sandalcioglu I, Bachmann HS (2013) Expression of aquaporin 5 and the AQP5 polymorphism A(−1364)C in association with peritumoral brain edema in meningioma patients. J Neurooncol 112(2):297–305. doi:10.1007/s11060-013-1064-z PubMed CrossRef
127.McCoy E, Sontheimer H (2007) Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia 55(10):1034–1043. doi:10.1002/glia.20524 PubMed PubMedCentral CrossRef
128.Shen L, Zhu Z, Huang Y, Shu Y, Sun M, Xu H, Zhang G, Guo R, Wei W, Wu W (2010) Expression profile of multiple aquaporins in human gastric carcinoma and its clinical significance. Biomed Pharmacother 64(5):313–318. doi:10.1016/j.biopha.2009.12.003 PubMed CrossRef
129.Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K, Sakai H (2009) Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci 59(2):113–122. doi:10.1007/s12576-008-0017-3 PubMed CrossRef
130.Sekine S, Shimada Y, Nagata T, Moriyama M, Omura T, Watanabe T, Hori R, Yoshioka I, Okumura T, Sawada S, Fukuoka J, Tsukada K (2012) Prognostic significance of aquaporins in human biliary tract carcinoma. Oncol Rep 27(6):1741–1747. doi:10.3892/or.2012.1747 PubMed
131.Avizienyte E, Brunton VG, Fincham VJ, Frame MC (2005) The SRC-induced mesenchymal state in late-stage colon cancer cells. Cells Tissues Organs 179(1–2):73–80. doi:10.1159/000084511 PubMed CrossRef
132.Zhao JH, Reiske H, Guan JL (1998) Regulation of the cell cycle by focal adhesion kinase. J Cell Biol 143(7):1997–2008PubMed PubMedCentral CrossRef
133.Schlaepfer DD, Hunter T (1997) Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J Biol Chem 272(20):13189–13195PubMed CrossRef
134.McCubrey JA, Abrams SL, Fitzgerald TL, Cocco L, Martelli AM, Montalto G, Cervello M, Scalisi A, Candido S, Libra M, Steelman LS (2015) Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis. Adv Biol Regul 57:75–101. doi:10.1016/j.jbior.2014.09.016 PubMed CrossRef
135.Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD (2000) FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2(5):249–256. doi:10.1038/35010517 PubMed CrossRef
136.Lamouille S, Xu J, Derynck R (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol 15(3):178–196. doi:10.1038/nrm3758 PubMed PubMedCentral CrossRef
137.Song T, Yang H, Ho JC, Tang SC, Sze SC, Lao L, Wang Y, Zhang KY (2015) Expression of aquaporin 5 in primary carcinoma and lymph node metastatic carcinoma of non-small cell lung cancer. Oncol Lett 9(6):2799–2804. doi:10.3892/ol.2015.3108 PubMed PubMedCentral
138.Sugihara I, Yoshida M, Shigenobu T, Takagi H, Maruyama K, Takeuchi N, Toda M, Inoue M, Nakada H (2006) Different progression of tumor xenografts between mucin-producing and mucin-non-producing mammary adenocarcinoma-bearing mice. Cancer Res 66(12):6175–6182. doi:10.1158/0008-5472.CAN-05-3663 PubMed CrossRef
139.Gluz O, Liedtke C, Gottschalk N, Pusztai L, Nitz U, Harbeck N (2009) Triple-negative breast cancer–current status and future directions. Ann Oncol 20(12):1913–1927. doi:10.1093/annonc/mdp492 PubMed CrossRef
140.Kasimir-Bauer S, Heubner M, Otterbach F, Kimmig R, Siffert W, Adamzik M (2009) Prognostic relevance of the AQP5 -1364C>A polymorphism in primary breast cancer. Mol Med Rep 2(4):645–650. doi:10.3892/mmr_00000151 PubMed CrossRef
141.Adamzik M, Frey UH, Bitzer K, Jakob H, Baba HA, Schmieder RE, Schneider MP, Heusch G, Peters J, Siffert W (2008) A novel-1364A/C aquaporin 5 gene promoter polymorphism influences the responses to salt loading of the renin-angiotensin-aldosterone system and of blood pressure in young healthy men. Basic Res Cardiol 103(6):598–610. doi:10.1007/s00395-008-0750-z PubMed CrossRef
142.Zou LB, Zhang RJ, Tan YJ, Ding GL, Shi S, Zhang D, He RH, Liu AX, Wang TT, Leung PC, Sheng JZ, Huang HF (2011) Identification of estrogen response element in the aquaporin-2 gene that mediates estrogen-induced cell migration and invasion in human endometrial carcinoma. J Clin Endocrinol Metab 96(9):E1399–E1408. doi:10.1210/jc.2011-0426 PubMed CrossRef
143.Pust A, Kylies D, Hube-Magg C, Kluth M, Minner S, Koop C, Grob T, Graefen M, Salomon G, Tsourlakis MC, Izbicki J, Wittmer C, Huland H, Simon R, Wilczak W, Sauter G, Steurer S, Krech T, Schlomm T, Melling N (2015) Aquaporin 5 expression is frequent in prostate cancer and shows a dichotomous correlation with tumor phenotype and PSA recurrence. Hum Pathol. doi:10.1016/j.humpath.2015.09.026 PubMed
144.Shu J, Lee JH, Harwalkar JA, Oh-Siskovic S, Stacey DW, Golubic M (1999) Adenovirus-mediated gene transfer of dominant negative Ha-Ras inhibits proliferation of primary meningioma cells. Neurosurgery 44(3):579–587 (discussion 587–578) PubMed CrossRef
145.Tamura K, Stecher G, Peterson D, Filipski A, Kumar S (2013) MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol 30(12):2725–2729. doi:10.1093/molbev/mst197 PubMed PubMedCentral CrossRef - 作者单位：Inês Direito (1) (2)
Ana Madeira (1) (2)
Maria Alexandra Brito (1) (2)
Graça Soveral (1) (2)
1. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003, Lisbon, Portugal
2. Department of Biochemistry and Human Biology, Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal - 刊物类别：Biomedical and Life Sciences
- 刊物主题：Life Sciences
Cell Biology
Biomedicine
Life Sciences
Biochemistry - 出版者：Birkh盲user Basel
- ISSN：1420-9071
文摘
Aquaporins, a highly conserved group of membrane proteins, are involved in the bidirectional transfer of water and small solutes across cell membranes taking part in many biological functions all over the human body. In view of the wide range of cancer malignancies in which aquaporin-5 (AQP5) has been detected, an increasing interest in its implication in carcinogenesis has emerged. Recent publications suggest that this isoform may enhance cancer cell proliferation, migration and survival in a variety of malignancies, with strong evidences pointing to AQP5 as a promising drug target and as a novel biomarker for cancer aggressiveness with high translational potential for therapeutics and diagnostics. This review addresses the structural and functional features of AQP5, detailing its tissue distribution and functions in human body, its expression pattern in a variety of tumors, and highlighting the underlying mechanisms involved in carcinogenesis. Finally, the actual progress of AQP5 research, implications in cancer biology and potential for cancer detection and prognosis are discussed.