Resistance training improves skeletal muscle insulin sensitivity in elderly offspring of overweight and obese mothers

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• 作者：Marco Bucci ; Ville Huovinen ; Maria Angela Guzzardi ; Suvi Koskinen…
• 关键词：Computed tomography ; Elderly ; Hyperinsulinaemic鈥揺uglycaemic clamp ; Insulin sensitivity ; Magnetic resonance ; Maternal obesity ; Positron emission tomography ; Resistance training ; Telomere shortening
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：59
• 期：1
• 页码：77-86
• 全文大小：1,093 KB
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• 作者单位：Marco Bucci (1)
  Ville Huovinen (1) (2) (3)
  Maria Angela Guzzardi (4)
  Suvi Koskinen (1)
  Juho R. Raiko (1)
  Heta Lipponen (1)
  Shaila Ahsan (1)
  Robert M. Badeau (1)
  Miikka-Juhani Honka (1)
  Jukka Koffert (1)
  Nina Savisto (1)
  Minna K. Salonen (5) (6)
  Jonathan Andersson (7)
  Joel Kullberg (7)
  Samuel Sandboge (5) (6)
  Patricia Iozzo (1) (4)
  Johan G. Eriksson (5) (6) (8) (9)
  Pirjo Nuutila (1) (10)
  
  1. Turku PET Centre, University of Turku, PO BOX 52, FIN-20521, Turku, Finland
  2. Department of Radiology, Faculty of Medicine, University of Turku, Turku, Finland
  3. Department of Radiology, Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
  4. Institute of Clinical Physiology, National Research Council, Pisa, Italy
  5. Folkh盲lsan Research Centre, Helsinki, Finland
  6. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
  7. Department of Radiology, Uppsala University, Uppsala, Sweden
  8. Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
  9. Vaasa Central Hospital, Vaasa, Finland
  10. Department of Endocrinology, Turku University Hospital, Turku, Finland
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis Maternal obesity predisposes offspring to adulthood morbidities, including type 2 diabetes. Type 2 diabetes and insulin resistance have been associated with shortened telomere length. First, we aimed to investigate whether or not maternal obesity influences insulin sensitivity and its relationship with leucocyte telomere length (LTL) in elderly women. Second, we tested whether or not resistance exercise training improves insulin sensitivity in elderly frail women.