Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

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• 作者：Marianne K. O. Grant ; Davis M. Seelig ; Leslie C. Sharkey…
• 关键词：Doxorubicin ; Cardiotoxicity ; Sex ; Cytochrome P450
• 刊名：Biology of Sex Differences
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：8
• 期：1
• 全文大小：2571KB
• 刊物主题：Human Physiology; Endocrinology;
• 出版者：BioMed Central
• ISSN：2042-6410
• 卷排序：8

文摘

BackgroundThere is inconclusive evidence about the role of sex as a risk factor for doxorubicin (DOX)-induced cardiotoxicity. Recent experimental studies have shown that adult female rats are protected against DOX-induced cardiotoxicity. However, the mechanisms of this sexual dimorphism are not fully elucidated. We have previously demonstrated that DOX alters the expression of several cytochrome P450 (CYP) enzymes in the hearts of male rats. Nevertheless, the sex-dependent effect of DOX on the expression of CYP enzymes is still not known. Therefore, in the present study, we determined the effect of acute DOX exposure on the expression of CYP genes in the hearts of both male and female C57Bl/6 mice.