Classification of Ambiguous Nerve Fiber Orientations in 3D Polarized Light Imaging

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• 作者：Melanie Kleiner (19)
  Markus Axer (19) (20)
  David Gr??el (19)
  Julia Reckfort (19)
  Uwe Pietrzyk (19) (20)
  Katrin Amunts (19) (21)
  Timo Dickscheid (19)
  
• 刊名：Lecture Notes in Computer Science
• 出版年：2012
• 出版时间：2012
• 年：2012
• 卷：7510
• 期：1
• 页码：214-222
• 全文大小：1376KB
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• 作者单位：Melanie Kleiner (19)
  Markus Axer (19) (20)
  David Gr??el (19)
  Julia Reckfort (19)
  Uwe Pietrzyk (19) (20)
  Katrin Amunts (19) (21)
  Timo Dickscheid (19)
  
  19. Institute of Neuroscience and Medicine (INM-1, INM-4), Research Center Jülich, Germany
  20. Department of Physics, University of Wuppertal, Germany
  21. Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Germany
  

文摘

3D Polarized Light Imaging (3D-PLI) has been shown to measure the orientation of nerve fibers in post mortem human brains at ultra high resolution. The 3D orientation in each voxel is obtained as a pair of angles, the direction angle and the inclination angle with unknown sign. The sign ambiguity is a major problem for the correct interpretation of fiber orientation. Measurements from a tiltable specimen stage, that are highly sensitive to noise, extract information, which allows drawing conclusions about the true inclination sign. In order to reduce noise, we propose a global classification of the inclination sign, which combines measurements with spatial coherence constraints. The problem is formulated as a second order Markov random field and solved efficiently with graph cuts. We evaluate our approach on synthetic and human brain data. The results of global optimization are compared to independent pixel classification with subsequent edge-preserving smoothing.