Does a Calculated “NAFLD Fibrosis Score-Reliably Negate the Need for Liver Biopsy in Patients Undergoing Bariatric Surgery?

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• 作者：Kerri A. Simo (1)
  Iain H. McKillop (5)
  Matthew T. McMillan (5)
  William A. Ahrens (2)
  Amanda L. Walters (3)
  Kyle J. Thompson (5)
  Timothy S. Kuwada (4)
  John B. Martinie (1)
  David A. Iannitti (1)
  Keith S. Gersin (4)
  David Sindram (1)
  
• 关键词：NAFLD ; Fibrosis ; Liver biopsy ; Roux ; en ; Y gastric bypass
• 刊名：Obesity Surgery
• 出版年：2014
• 出版时间：January 2014
• 年：2014
• 卷：24
• 期：1
• 页码：15-21
• 全文大小：285 KB
• 作者单位：Kerri A. Simo (1)
  Iain H. McKillop (5)
  Matthew T. McMillan (5)
  William A. Ahrens (2)
  Amanda L. Walters (3)
  Kyle J. Thompson (5)
  Timothy S. Kuwada (4)
  John B. Martinie (1)
  David A. Iannitti (1)
  Keith S. Gersin (4)
  David Sindram (1)
  
  1. HPB Surgery, Department of Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 600, Charlotte, NC, 28204, USA
  5. Department of Surgery, Carolinas Medical Center, 1025 Morehead Medical Drive, Suite 600, Charlotte, NC, 28204, USA
  2. Department of Pathology, Carolinas Medical Center, Charlotte, NC, USA
  3. Minimally Invasive Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA
  4. Bariatric Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA
  
• ISSN：1708-0428

文摘

Background Nonalcoholic fatty liver disease (NAFLD) represents the most common cause of chronic liver disease in the USA. Biopsy has been the standard for determining fibrosis but is invasive, costly, and associated with risk. Previous studies report a calculated “NAFLD fibrosis scores-(cNFS) as a means to overcome the need for biopsy. We compared cNFS versus biopsy-pathological scoring for patients undergoing bariatric surgery. Methods We retrospectively reviewed patients with available preoperative labs and patient information undergoing Roux-en-Y gastric bypass (RYGBP) surgery at a single institution over a 5.5-year period. Biopsy samples were blind scored by a single hepatopathologist and compared with scores calculated using a previously reported cNFS. Results Of the 225 patients that met the inclusion criteria, the mean body mass index was 44.6?±-.4?kg/m2 and 85?% were female. Using the cNFS, 39.6?% of patients were categorized into low fibrosis, 52?% indeterminate, and 8.4?% high fibrosis groups. Analysis of fibrosis by pathology scoring demonstrated 2 of 89 (2.2?%) and 7 of 110 (3.4?%) had significant fibrosis in the low and intermediate groups, respectively. Conversely, in the high fibrosis group calculated by cNFS, only 6 of 19 (31.6?%) exhibited significant fibrosis by pathology scoring. Conclusions No definitive model for accurately predicting presence of NAFLD and fibrosis currently exits. Furthermore, under no circumstances should a clinical “NAFLD fibrosis score-replace liver biopsy at this time for RYGBP patients.