Solitary Peutz-Jeghers type hamartomatous polyps in the duodenum are not always associated with a low risk of cancer: two case reports

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• 作者：Yusuke Sekino (1)
  Masahiko Inamori (1)
  Mitsuru Hirai (2)
  Kaori Suzuki (1)
  Kaoru Tsuzawa (2)
  Keiko Akimoto (2)
  Ayako Takahata (2)
  Nobutaka Fujisawa (2)
  Kumiko Saito (2)
  Akisa Tsunemi (3)
  Michio Tanaka (3)
  Hiroshi Iida (1)
  Yasunari Sakamoto (1)
  Hirokazu Takahashi (1)
  Tomoko Koide (1)
  Chikako Tokoro (1)
  Yasunobu Abe (1)
  Atsushi Nakajima (1)
  Shin Maeda (1)
  Shigeru Koyama (2)
  
• 刊名：Journal of Medical Case Reports
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：5
• 期：1
• 全文大小：1484KB
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• 作者单位：Yusuke Sekino (1)
  Masahiko Inamori (1)
  Mitsuru Hirai (2)
  Kaori Suzuki (1)
  Kaoru Tsuzawa (2)
  Keiko Akimoto (2)
  Ayako Takahata (2)
  Nobutaka Fujisawa (2)
  Kumiko Saito (2)
  Akisa Tsunemi (3)
  Michio Tanaka (3)
  Hiroshi Iida (1)
  Yasunari Sakamoto (1)
  Hirokazu Takahashi (1)
  Tomoko Koide (1)
  Chikako Tokoro (1)
  Yasunobu Abe (1)
  Atsushi Nakajima (1)
  Shin Maeda (1)
  Shigeru Koyama (2)
  
  1. Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura Kanazawa-ku, Yokohama, 236-0004, Japan
  2. Department of Gastroenterology, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan
  3. Department of Pathology, Tokyo Metropolitan Hiroo Hospital, 2-34-10 Ebisu, Shibuya-ku, Tokyo, 150-0013, Japan
  

文摘

Introduction A hamartomatous polyp without associated mucocutaneous pigmentation or a family history of Peutz-Jeghers Syndrome is diagnosed as a solitary Peutz-Jeghers type hamartomatous polyp. As compared with Peutz-Jeghers Syndrome, Peutz-Jeghers type hamartomatous polyps are diagnosed with a lower risk of cancer and are regarded as a different disorder. Case presentation In case one, we describe an 84-year-old Japanese man with a 14 mm duodenal polyp. Endoscopic mucosal resection was performed and histological examination showed findings suggestive of a hamartomatous polyp with a focus of well-differentiated adenocarcinoma. In case two, we describe a 76-year-old Japanese man who had been treated for prostate, rectal and lung cancer. Upper gastrointestinal endoscopy revealed a duodenal polyp measuring 15 mm in diameter. Endoscopic mucosal resection was performed, and histological examination showed findings suggestive of a hamartomatous polyp. Liver and thyroid cancers were found after the endoscopic treatment. Conclusion Although duodenal solitary hamartomatous polyps are associated with a lower risk of cancer, four patients, including our cases, have been diagnosed with cancerous polyps. Patients with duodenal solitary hamartomatous polyps should be treated by endoscopic or surgical resection and need whole-body screening.