Garcin syndrome as the initial presentation of metastatic adenocarcinoma of the prostate

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• 作者：Hiroki Kubota (1)
  Hiromichi Naruyama (1)
  Masahito Hirose (1)
  Katsuhiro Fukuta (1)
  Yasue Kubota (2)
  Yasuyuki Yamada (1)
  Kenjiro Kohri (2)
  
• 关键词：Garcin syndrome ; Prostate cancer ; Skull base metastasis
• 刊名：International Cancer Conference Journal
• 出版年：2012
• 出版时间：April 2012
• 年：2012
• 卷：1
• 期：2
• 页码：113-115
• 全文大小：279KB
• 参考文献：1. Jemal A, Siegel R, Ward E (2009) Cancer statistics, 2009. CA Cancer J Clin 59:225-49 CrossRef
  2. Adams R, Victor M, Ropper AH (1997) Principles of neurology. In: The major categories of neurologic diseases. 6th edn. McGraw-Hill, New York, p 685
  3. Long MA, Husband JE (1999) Features of unusual metastases from prostate cancer. Br J Radiol 72(862):933-41
  4. McDermott RS, Anderson PR, Greenberg RE, Milestone BN, Hudes GR (2004) Cranial nerve deficits in patients with metastatic prostate carcinoma: clinical features and treatment outcomes. Cancer 101(7):1639-643 CrossRef
  5. Greenberg HS, Deck MD, Vikram B, Chu FC, Posner JB (1981) Metastasis to the base of the skull; clinical findings in 43 patients. Neurology 31(5):530-37
  6. Seymore CH, Peeples WJ (1988) Cranial nerve involvement with carcinoma of prostate. Urology 31(3):211-13 CrossRef
  7. Svare A, Fossa SD, Heier MS (1988) Cranial nerve dysfunction in metastatic cancer of the prostate. Br J Urol 61(5):441-44 CrossRef
  8. Ransom DT, Dinapoli RP, Richardson RL (1990) Cranial nerve lesions due to base of the skull metastases in prostate carcinoma. Cancer 65(3):586-89 CrossRef
  9. O’Sullivan JM, Norman AR, McNair H, Dearnaley DP (2004) Cranial nerve palsies in metastatic prostate cancer—results of base of skull radiotherapy. Radiother Oncol 70(1):87-0 CrossRef
  10. Kolias AG, Derham C, Mankad K, Hasegawa H, O’Kane R, Ismail A, Phillips NI (2010) Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature. Acta Neurochir (Wien) 152(7):1251-255 CrossRef
  
• 作者单位：Hiroki Kubota (1)
  Hiromichi Naruyama (1)
  Masahito Hirose (1)
  Katsuhiro Fukuta (1)
  Yasue Kubota (2)
  Yasuyuki Yamada (1)
  Kenjiro Kohri (2)
  
  1. Department of Urology, Kainan Hospital, 396 Minamihonden, Maegasu-cho, Yatomi, Aichi, 498-8502, Japan
  2. Department of Nephro-urology, Nagoya City University Graduate School of Medical Science, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan
  

文摘

We describe an unusual case of metastasis of the skull base from prostate cancer. A 64-year-old man was referred for progressive cranial nerve palsies. Brain magnetic resonance imaging showed a metastatic tumor in the right petrous bone. He was presenting Garcin syndrome indicating involvement of the right III, IV, V, VI, VII, VIII, IX, X, and XII cranial nerves. The serum PSA level was 5118?ng/mL (standard threshold 4?ng/mL). A transrectal needle biopsy was performed, and poorly differentiated adenocarcinoma was detected in the prostate. Therefore, he was finally diagnosed with skull base metastasis of the prostate cancer. Androgen deprivation therapy and external beam radiation therapy to the skull base resulted in complete resolution of the cranial nerve palsies for more than 30?months. This is the first reported case of metastatic prostate cancer presenting as Garcin syndrome.