Anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion: a case report

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• 作者：Tomoe Abe (18)
  Masaru Suzuki (18)
  Kaoruko Shimizu (18)
  Naofumi Shinagawa (18)
  Satoshi Oizumi (18)
  Yoshihiro Matsuno (19)
  Masaya Miyazaki (20)
  Mishie Tanino (20)
  Shinya Tanaka (20)
  Masaharu Nishimura (18)
  
  18. First Department of Medicine ; Hokkaido University School of Medicine ; North 15 West 7 ; Kita-ku ; Sapporo ; 060-8638 ; Japan
  19. Department of Surgical Pathology ; Hokkaido University Hospital ; North 14 West 5 ; Kita-ku ; Sapporo ; 060-8648 ; Japan
  20. Department of Cancer Pathology ; Hokkaido University Graduate School of Medicine ; North 15 West 7 ; Kita-ku ; Sapporo ; 060-8638 ; Japan
  
• 关键词：Anaplastic transformation ; Lung metastasis ; Malignant pleural effusion ; Papillary thyroid carcinoma
• 刊名：Journal of Medical Case Reports
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：8
• 期：1
• 全文大小：958 KB
• 参考文献：1. Patel, KN, Shaha, AR (2006) Poorly differentiated and anaplastic thyroid cancer. Cancer Control 13: pp. 119-128
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  4. Sumida, T, Hamakawa, H, Imaoka, M, Okamoto, N, Takarada, M, Taniola, H, Ueda, N, Nose, M (2001) A case of submandibular malignant rhabdoid tumor transformed from papillary thyroid carcinoma. J Oral Pathol Med 30: pp. 443-447 CrossRef
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  14. Sera, N, Ashizawa, K, Ando, T, Ide, A, Abe, Y, Usa, T, Tominaga, T, Ejima, E, Hayashi, T, Shimokawa, I, Eguchi, K (2000) Anaplastic changes associated with p53 gene mutation in differentiated thyroid carcinoma after insufficient radioactive iodine (131I) therapy. Thyroid 10: pp. 975-979 CrossRef
  
• 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
• 出版者：BioMed Central
• ISSN：1752-1947

文摘

Introduction Anaplastic transformation of well-differentiated papillary thyroid carcinoma at distant metastasis sites is rare. To the best of our knowledge, this is the first report of an autopsy case of anaplastic transformation of papillary thyroid carcinoma in multiple lung metastases presenting with a malignant pleural effusion. Case presentation We report an autopsy case of a 61-year-old Japanese man with anaplastic transformation of papillary thyroid carcinoma with multiple lung metastases presenting with a malignant pleural effusion, which was difficult to diagnose by cytological examination before the autopsy. He presented with a 1-month history of progressive dyspnea, and examination of the left pleural effusion revealed a bloody exudate with an increase in thyroglobulin; however, malignant cells in the pleural fluid were negative for thyroglobulin. Conclusion It is important to be aware that anaplastic transformation of differentiated thyroid carcinoma could develop in lung metastases and could be a cause of a malignant pleural effusion.