Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

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• 作者：Masayoshi Arai (1)
  Asami Hayashi (1)
  Mari Sobou (1)
  Shunsuke Ishida (1)
  Takashi Kawachi (1)
  Naoyuki Kotoku (1)
  Motomasa Kobayashi (1)
  
• 关键词：Senegasaponins ; Polygala senega ; Angiogenesis ; Cancer ; HUVECs ; Tubular formation
• 刊名：Journal of Natural Medicines
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：65
• 期：1
• 页码：149-156
• 全文大小：520KB
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• 作者单位：Masayoshi Arai (1)
  Asami Hayashi (1)
  Mari Sobou (1)
  Shunsuke Ishida (1)
  Takashi Kawachi (1)
  Naoyuki Kotoku (1)
  Motomasa Kobayashi (1)
  
  1. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565-0871, Japan
  
• ISSN：1861-0293

文摘

Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-strong class="a-plus-plus">5) showed anti-proliferative activity against HUVECs with IC50 values in the range 0.6-.2?μM, and the selective index was 7-00-fold in comparison with those for several cancer cell lines, while the desacyl mixture of senegasaponins (6) and tenuifolin (7) lost anti-proliferative activity, indicating that the 28-O-glycoside moiety and methoxycinnamoyl group were essential for the HUVEC-selective growth inhibition of senegasaponins. Senegin III (2) inhibited the vascular endothelial growth factor (VEGF)-induced in vitro tubular formation of HUVECs and basic fibroblast growth factor (bFGF)-induced in vivo neovascularization in the mouse Matrigel plug assay. Moreover, senegin III (2) suppressed tumor growth in the ddY mice s.c.-inoculated murine sarcoma S180 cells. The analysis of the action mechanism of senegin III (2) suggested that the induction of pigment epithelium-derived factor (PEDF) would contribute to the anti-angiogenic effects of senegasaponins.