Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior
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- 作者：Michio Nomura ; Ichiro Kusumi ; Masayuki Kaneko ; Takuya Masui ; Makoto Daiguji ; Takeji Ueno ; Tsukasa Koyama and Yasuyuki Nomura
- 关键词：Impulsivity ; 5 ; HT2A receptor ; Polymorphism ; Japanese participants ; Commission error ; Disinhibition
- 刊名：Psychopharmacology
- 出版年：2006
- 出版时间：July 2006
- 年：2006
- 卷：187
- 期：1
- 页码：30-35
- 全文大小：129 KB
文摘
Rationale and objective Impulsive behavior has been suggested to occur due to a dysfunction of serotonergic 5-HT neurotransmission. After evaluation by a self-reporting measure, a polymorphism in the promoter of the 5-HT2A receptor gene has been proposed to underlie the impulsive behavior; however, this hypothesis is not convincing. In this study, we examined whether this 5-HT2A receptor gene polymorphism is involved in impulsive aggression by evaluating a behavioral task (go/no-go task) in normal volunteers.