Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case

详细信息    查看全文

• 作者：Sae Murakami (1)
  Tetsuo Ajiki (1)
  Kimihiko Ueno (1)
  Hidehiro Sawa (1)
  Shinobu Tsuchida (1)
  Izuru Otsubo (1)
  Yuko Yoshida (1)
  Kenta Shinozaki (1)
  Taro Okazaki (1)
  Ippei Matsumoto (1)
  Takumi Fukumoto (1)
  Yonson Ku (1)
  
• 关键词：Hilar cholangiocarcinoma ; Young adults ; Anomalous arrangement of the pancreaticobiliary duct system
• 刊名：Surgery Today
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：44
• 期：7
• 页码：1350-1354
• 全文大小：
• 参考文献：1. Yamamoto M, Ariizumi S. Surgical outcomes of intrahepatic cholangiocarcinoma. Surg Today. 2011;41:896-02. CrossRef
  2. Nuzzo G, Giuliante F, Ardito F, Giovannini I, Aldrighetti L, Belli G, et al. Improvement in perioperative and long-term outcome after surgical treatment of hilar cholangiocarcinoma: results of an Italian multicenter analysis of 440 patients. Arch Surg. 2012;147:26-4. CrossRef
  3. Hasumi A, Matsui H, Sugioka A, Uyama I, Komori Y, Fujita J, et al. Precancerous conditions of biliary tract cancer in patients with pancreaticobiliary maljunction: reappraisal of nationwide survey in Japan. J Hepatobiliary Pancreat Surg. 2000;7:551-. CrossRef
  4. Nakamura H, Katayose Y, Rikiyama T, Onogawa T, Yamamoto K, Yoshida H, et al. Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maljunction and congenital biliary cystic disease. J Hepatobiliary Pancreat Surg. 2008;15:554-. CrossRef
  5. Funabiki T, Matsubara T, Miyakawa S, Ishihara S. Pancreaticobiliary maljunction and carcinogenesis to biliary and pancreatic malignancy. Langenbecks Arch Surg. 2009;394:159-9. CrossRef
  6. Deneau M, Adler DG, Schwartz JJ, Hutson W, Sorensen J, Book L, et al. Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011;52:617-0. CrossRef
  7. Bjornsson E, Angulo P. Cholangiocarcinoma in young individuals with and without primary sclerosing cholangitis. Am J Gastroenterol. 2007;102:1677-2. CrossRef
  8. Saxena A, Chua TC, Chu FC, Morris DL. Improved outcomes after aggressive surgical resection of hilar cholangiocarcinoma: a critical analysis of recurrence and survival. Am J Surg. 2011;202:310-0. CrossRef
  9. Ebata T, Nagino M, Kamiya J, Uesaka K, Nagasaka T, Nimura Y. Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases. Ann Surg. 2003;238:720-. CrossRef
  10. Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N, et al. Prognostic factors after surgical resection for intrahepatic, hilar, and distal cholangiocarcinoma. Ann Surg Oncol. 2011;18:651-. CrossRef
  11. Kayahara M, Nagakawa T. Recent trends of gallbladder cancer in Japan: an analysis of 4,770 patients. Cancer. 2007;110:572-0. CrossRef
  12. Yeh CN, Jan YY, Chen MF. Influence of age on surgical treatment of peripheral cholangiocarcinoma. Am J Surg. 2004;187:559-3. CrossRef
  13. Matsubara T, Funabiki T, Jinno O, Sakurai Y, Hasegawa S, Imazu H, et al. p53 gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction. J Hepatobiliary Pancreat Surg. 1999;6:286-3. CrossRef
  14. Noda Y, Fujita N, Kobayashi G, Ito K, Horaguchi J, Takasawa O, et al. Histological study of gallbladder and bile duct epithelia in patients with anomalous arrangement of the pancreaticobiliary ductal system: comparison between those with and without a dilated common bile duct. J Gastroenterol. 2007;42:211-. CrossRef
  15. Nagai M, Watanabe M, Iwase T, Yamao K, Isaji S. Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction. World J Surg. 2002;26:91-. CrossRef
  16. Suto T, Habano W, Sugai T, Uesugi N, Kanno S, Saito K, et al. Infrequent microsatellite instability in biliary tract cancer. J Surg Oncol. 2001;76:121-. CrossRef
  17. Rashid A, Ueki T, Gao YT, Houlihan PS, Wallace C, Wang BS, et al. K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin Cancer Res. 2002;8:3156-3.
  18. Pandey M. Environmental pollutants in gallbladder carcinogenesis. J Surg Oncol. 2006;93:640-. CrossRef
  19. Nagino M, Nimura Y, Nishio H, Ebata T, Igami T, Matsushita M, et al. Hepatectomy with simultaneous resection of the portal vein and hepatic artery for advanced perihilar cholangiocarcinoma: an audit of 50 consecutive cases. Ann Surg. 2010;252:115-3. CrossRef
  20. Skipworth JR, Olde Damink SW, Imber C, Bridgewater J, Pereira SP, Malago M. Review article: surgical, neo-adjuvant and adjuvant management strategies in biliary tract cancer. Aliment Pharmacol Ther. 2011;34:1063-8.
  21. Murakami Y, Uemura K, Sudo T, Hayashidani Y, Hashimoto Y, Nakamura H, et al. Gemcitabine-based adjuvant chemotherapy improves survival after aggressive surgery for hilar cholangiocarcinoma. J Gastrointest Surg. 2009;13:1470-. CrossRef
  22. Eudaly JA, Tizzano JP, Higdon GL, Todd GC. Developmental toxicity of gemcitabine, an antimetabolite oncolytic, administered during gestation to CD-1 mice. Teratology. 1993;48:365-1. CrossRef
  23. Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol. 2000;169:123-1. CrossRef
  24. Andersen CY, Kristensen SG, Greve T, Schmidt KT. Cryopreservation of ovarian tissue for fertility preservation in young female oncological patients. Future Oncol. 2012;8:595-08. CrossRef
  25. Chui AK, Island ER, Rao AR, Lau WY. The longest survivor and first potential cure of an advanced cholangiocarcinoma by ex vivo resection and autotransplantation: a case report and review of the literature. Am Surg. 2003;69:441-.
  26. Klein WM, Molmenti EP, Colombani PM, Grover DS, Schwarz KB, Boitnott J, et al. Primary liver carcinoma arising in people younger than 30?years. Am J Clin Pathol. 2005;124:512-. CrossRef
  27. Fujiwara H, Kuroda D, Imano M, Nomura H, Kato M, Ohyanagi H. Early carcinoma of the gallbladder in a young female resected by laparoscopic cholecystectomy. Acta Med Kinki Univ. 1997;22:123-.
  28. Temizkan M, Ouwendijk JT, Middelkoop MP, Blankenstein M, ten Kate FJ, Tytgat GN. A young female with a cholangiocarcinoma in the past: is pregnancy allowed? Acta Gastroenterol Latinoam. 1996;26:31-.
  29. Suehiro T, Matsumata T, Iguchi T, Sanefuji K, Nomoto KI, Taketomi A, et al. Immunohistochemical examination of a resected advanced hilar cholangiocarcinoma arising in a 29-year-old male without primary sclerosing cholangitis. Case Rep Gastroenterol. 2010;4:144-2. CrossRef
  
• 作者单位：Sae Murakami (1)
  Tetsuo Ajiki (1)
  Kimihiko Ueno (1)
  Hidehiro Sawa (1)
  Shinobu Tsuchida (1)
  Izuru Otsubo (1)
  Yuko Yoshida (1)
  Kenta Shinozaki (1)
  Taro Okazaki (1)
  Ippei Matsumoto (1)
  Takumi Fukumoto (1)
  Yonson Ku (1)
  
  1. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan
  
• ISSN：1436-2813

文摘

A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent curative resection involving extended left hepatectomy and segmental portal vein resection. The pathological findings demonstrated a well-differentiated tubular adenocarcinoma of the bile duct with regional lymph node metastasis (stage IIIB according to the UICC TNM classification), as well as the overexpression of p53 proteins and the K-ras gene mutation in tumor cells. The patient has shown no evidence of recurrence in the 10?months since the operation. Although there are several reports of relatively young adults with cholangiocarcinoma, the majority of such patients demonstrate either an anomalous arrangement of the pancreaticobiliary duct system or primary sclerosing cholangitis. The absence of any morphological abnormalities in this patient’s biliary system implicates de novo carcinogenesis as the most likely cause of the cholangiocarcinoma.