Vitrified-warmed ovarian tissue autotransplantation into ovariectomized mice restores sufficient ovarian function to support full-term pregnancy

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• 作者：Hiromichi Matsumoto (1)
  Kenji Ezoe (1)
  Akinori Mitsui (1)
  Emiko Fukui (1)
  Masanori Ochi (2)
  Midori Yoshizawa (1)
  
• 关键词：Autotransplantation ; Ovarian tissue ; Pregnancy ; Uterus ; Vitrification
• 刊名：Reproductive Medicine and Biology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：10
• 期：3
• 页码：185-191
• 全文大小：1111KB
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• 作者单位：Hiromichi Matsumoto (1)
  Kenji Ezoe (1)
  Akinori Mitsui (1)
  Emiko Fukui (1)
  Masanori Ochi (2)
  Midori Yoshizawa (1)
  
  1. Laboratory of Animal Breeding and Reproduction, Division of Animal Science, Faculty of Agriculture, Utsunomiya University, Utsunomiya, Tochigi, 321-8505, Japan
  2. Ochi Yume Clinic, Nagoya, Aichi, 460-0002, Japan
  

文摘

Purpose Our previous study demonstrated that heterotopic autotransplantation of fresh ovarian tissue followed by transfer of blastocysts supported full-term pregnancy in the mouse. In the present study, to address whether vitrified-warmed ovarian tissue has the potential to support uterine preparation for implantation and subsequent pregnancy to full term, we examined vitrified-warmed ovarian tissue autotransplantation (VOAT) in mice. Methods VOAT into kidney capsules was performed for sexual cycle-ceased mice after 7?days of ovariectomy. Uterine potential of decidualization was examined by oil infusion on day 4 of pseudopregnancy. Immunohistochemical analysis was performed to examine the potential in VOAT ovarian tissues. Blastocysts were transferred into uteri on day 4 of pseudopregnancy. Results In VOAT mice, uterine decidualization on day 8 of pseudopregnancy was the same as that in intact mice. Blastocyst transfer into the pseudopregnant VOAT mice showed the same rates of pregnancy and live birth pups as intact mice, while less steroidogenesis in the corpus luteum was detected in VOAT mice. Conclusions The autotransplantation of vitrified-warmed ovarian tissues after 7?days of ovariectomy restored their sexual cycle and then supported their pregnancy and production of offspring.