Lactate and glucose measurement in subepidermal tissue using minimally invasive microperfusion needle

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• 作者：Noriko Tsuruoka ; Kenji Ishii ; Tadao Matsunaga ; Ryoichi Nagatomi…
• 关键词：Microperfusion ; Lactate measurement ; Glucose measurement ; Subepidermal ; Non ; planar microfabrication
• 刊名：Biomedical Microdevices
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：18
• 期：1
• 全文大小：1,069 KB
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• 作者单位：Noriko Tsuruoka (1)
  Kenji Ishii (1)
  Tadao Matsunaga (2)
  Ryoichi Nagatomi (3)
  Yoichi Haga (3)
  
  1. Graduate School of Engineering, Tohoku University, 6-6 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, Japan
  2. Micro System Integration Center (μSIC), Tohoku University, 6-6 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, Japan
  3. Graduate School of Biomedical Engineering, Tohoku University, 6-6 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi, Japan
  
• 刊物类别：Engineering
• 刊物主题：Biomedical Engineering
  Biophysics and Biomedical Physics
  Nanotechnology
  Engineering Fluid Dynamics
  
• 出版者：Springer Netherlands
• ISSN：1572-8781

文摘

Knowing the concentrations of biological substances can help ascertain physiological and pathological states. In the present study, a minimally invasive microperfusion needle was developed for measuring the concentrations of biological substances in subepidermal tissue. The microperfusion needle has a flow channel with a perforated membrane through which biological substances from subepidermal tissue are extracted. Since this device uses a thin steel acupuncture needle as the base substrate, it has sufficient rigidity for insertion through the skin. The efficacy of the needle was examined by measuring lactate and glucose concentrations in mice. Lactate was injected intraperitoneally, and changes in lactate concentrations in subepidermal tissue over time were measured using the device. Lactate concentrations of blood were also measured as a reference. Lactate was successfully collected using the microperfusion needle, and the lactate concentration of perfused saline was significantly correlated with blood lactate concentration. Glucose solution was administered orally, and the glucose concentration of perfused saline was also correlated with blood glucose concentration. The newly developed microperfusion needle can be used for minimally invasive monitoring of the concentrations of biological substances.