Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years
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- 作者：Albert Rosenberger (1)
Thomas Illig (2)
Katrin Korb (1)
Norman Klopp (2)
Vera Zietemann (2)
Gabi W?lke (2)
Eckart Meese (3)
Gerhard Sybrecht (4)
Florian Kronenberg (5)
Matthias Cebulla (6)
Maria Degen (7)
Peter Drings (8)
Andreas Gr?schel (4)
Nikolaus Konietzko (9)
Karsten grosse Kreymborg (10)
Karl H?u?inger (11)
Gerd H?ffken (12)
Bettina Jilge (13)
You-Dschun Ko (14)
Harald Morr (7)
Christine Schmidt (12)
E-Wilhelm Schmidt (13)
Dagmar T?uscher (15)
Heike Bickeb?ller (1)
H-Erich Wichmann (16) (2) - 刊名：BMC Cancer
- 出版年：2008
- 出版时间：December 2008
- 年：2008
- 卷：8
- 期：1
- 全文大小：620KB
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74. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/60/prepub - 作者单位：Albert Rosenberger (1)
Thomas Illig (2)
Katrin Korb (1)
Norman Klopp (2)
Vera Zietemann (2)
Gabi W?lke (2)
Eckart Meese (3)
Gerhard Sybrecht (4)
Florian Kronenberg (5)
Matthias Cebulla (6)
Maria Degen (7)
Peter Drings (8)
Andreas Gr?schel (4)
Nikolaus Konietzko (9)
Karsten grosse Kreymborg (10)
Karl H?u?inger (11)
Gerd H?ffken (12)
Bettina Jilge (13)
You-Dschun Ko (14)
Harald Morr (7)
Christine Schmidt (12)
E-Wilhelm Schmidt (13)
Dagmar T?uscher (15)
Heike Bickeb?ller (1)
H-Erich Wichmann (16) (2)
1. Department of Genetic Epidemiology, Georg-August University of G?ttingen, Medical School, Germany
2. Institute of Epidemiology, GSF-National Research Centre for Environment and Health, Germany
3. Institute of Human Genetics, University of the Saarland, Germany
4. Institute of Internal Medicine V, Medical School, University of the Saarland, Germany
5. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Austria
6. Municipal Hospital Sankt Georg, Leipzig, Germany
7. Clinic of Pneumology, Waldhof Elgershausen, Greifenstein, Germany
8. Department of Oncology/Internal Medicine, Thoraxklinic of the Univeristy Hospital Heidelberg GmbH, Heidelberg, Germany
9. Department of Pneumology, University Hospital Essen, Ruhrlandklinik, Germany
10. Centre for Internal Medicine, University Hospital Leipzig, Germany
11. Clinic of Pneumology München-Gauting, Munich, Germany
12. Division Internal Medicine, Clinic Coswig GmbH, Coswig, Germany
13. Chemnitz Hospital, Clinic for Internal Medicine, Chemnitz, Germany
14. Department of Oncology, University Hospital Bonn, Germany
15. Wald-Hospital Gera GmbH, II. Medical Clinic, Gera, Germany
16. Institute of Medical Data Management, Biometry and Epidemiology, Ludwig Maximilians University Munich, Chair of Epidemiology, Germany - ISSN：1471-2407
文摘
Background Early onset lung cancer shows some familial aggregation, pointing to a genetic predisposition. This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients younger than 51 years at diagnosis. Methods 246 patients with a primary, histologically or cytologically confirmed neoplasm, recruited from 2000 to 2003 in major lung clinics across Germany, were matched to 223 unrelated healthy controls. 11 single nucleotide polymorphisms of genes with reported associations to lung cancer have been genotyped. Results Genetic associations or gene-smoking interactions was found for GPX1(Pro200Leu) and EPHX1(His113Tyr). Carriers of the Leu-allele of GPX1(Pro200Leu) showed a significant risk reduction of OR = 0.6 (95% CI: 0.4-.8, p = 0.002) in general and of OR = 0.3 (95% CI:0.1-.8, p = 0.012) within heavy smokers. We could also find a risk decreasing genetic effect for His-carriers of EPHX1(His113Tyr) for moderate smokers (OR = 0.2, 95% CI:0.1-.7, p = 0.012). Considered both variants together, a monotone decrease of the OR was found for smokers (OR of 0.20; 95% CI: 0.07-.60) for each protective allele. Conclusion Smoking is the most important risk factor for young lung cancer patients. However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.