CD57 in human natural killer cells and T-lymphocytes

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• 作者：Hassen Kared ; Serena Martelli ; Tze Pin Ng…
• 关键词：CD57 ; KLRG1 ; NKG2C ; Memory NK cells ; Senescence ; NK maturation
• 刊名：Cancer Immunology, Immunotherapy
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：65
• 期：4
• 页码：441-452
• 全文大小：846 KB
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• 作者单位：Hassen Kared (1)
  Serena Martelli (1) (2)
  Tze Pin Ng (3)
  Sylvia L.F. Pender (2)
  Anis Larbi (1) (4) (5)
  
  1. Singapore Immunology Network (SIgN), Aging and Immunity Program, Agency for Science Technology and Research (A*STAR), 8A Biomedical Grove #3 Immunos, Singapore, 138648, Republic of Singapore
  2. Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
  3. Gerontological Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
  4. Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
  5. School of Biological Sciences, Nanyang Technological University, Singapore, Republic of Singapore
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Cancer Research
  Immunology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0851

文摘

The CD57 antigen (alternatively HNK-1, LEU-7, or L2) is routinely used to identify terminally differentiated ‘senescent’ cells with reduced proliferative capacity and altered functional properties. In this article, we review current understanding of the attributes of CD57-expressing T-cells and NK cells in both health and disease and discuss how this marker can inform researchers about their likely functions in human blood and tissues in vivo. While CD57 expression on human lymphocytes indicates an inability to proliferate, these cells also display high cytotoxic potential, and CD57pos NK cells exhibit both memory-like features and potent effector functions. Accordingly, frequencies of CD57-expressing cells in blood and tissues have been correlated with clinical prognosis in chronic infections or various cancers and with human aging. Functional modulation of senescent CD57pos T-cells and mature CD57pos NK cells may therefore represent innovative strategies for protection against human immunological aging and/or various chronic diseases.