Thyroglossal duct cyst cancer most likely arises from a thyroid gland remnant

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• 作者：Esther D. Rossi (1)
  Maurizio Martini (1)
  Patrizia Straccia (1)
  Alessandra Cocomazzi (1)
  Ilaria Pennacchia (1)
  Luca Revelli (2)
  Armando Rossi (3)
  Celestino Pio Lombardi (2)
  Luigi M. Larocca (1)
  Guido Fadda (1)
  
• 关键词：Thyroid papillary carcinoma ; Thyroglossal cyst ; BRAF mutation
• 刊名：Virchows Archiv
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：465
• 期：1
• 页码：67-72
• 全文大小：522 KB
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• 作者单位：Esther D. Rossi (1)
  Maurizio Martini (1)
  Patrizia Straccia (1)
  Alessandra Cocomazzi (1)
  Ilaria Pennacchia (1)
  Luca Revelli (2)
  Armando Rossi (3)
  Celestino Pio Lombardi (2)
  Luigi M. Larocca (1)
  Guido Fadda (1)
  
  1. Division of Anatomic Pathology and Histology, Università Cattolica del Sacro Cuore, “Agostino Gemelli-School of Medicine, Largo Francesco Vito, 1-00168, Rome, Italy
  2. Division of Endocrine Surgery- Università Cattolica del Sacro Cuore, “Agostino Gemelli-School of Medicine, Rome, Italy
  3. Division of Anatomic Pathology and Histology, Hospital “Misericordia-of Grosseto, Grosseto, Italy
  
• ISSN：1432-2307

文摘

Thyroglossal duct cancer is a rare entity, occurring in 1.5?% of all thyroglossal duct cysts (TDC). A definitive consensus about its neoplastic origin has not been established as two contrasting theories exist, one proposing an origin in extra-thyroid remnants and the other a metastatic localization of a primary thyroid cancer. We compare morphological and molecular characteristics of both thyroglossal and thyroid carcinomas in a case series from our institute. We evaluated histology of 80 TDC. In 12 cases, prior cytological evaluation had been performed by liquid-based cytology (LBC). The BRAF gene was examined for mutations, and the histology of both thyroglossal duct and synchronous thyroid carcinoma was reevaluated. In 9 out of 80 (11?%) TDC cases, a papillary thyroid cancer (PTC) was diagnosed. In five out of nine (56?%) thyroglossal carcinomas, a synchronous thyroid cancer was diagnosed: 3 PTC and 2 follicular variant PTC (FVPC). In five thyroglossal carcinomas, mutated BRAF (V600E) was found, three in PTC and in thyroglossal as well as in the synchronous tumor in the thyroid. All the patients are in a disease-free status and still alive. Our results suggest that the majority of thyroglossal carcinomas most likely develop as a primary malignancy from a thyroid remnant. Neither the presence of V600E BRAF mutations nor that of a well-differentiated thyroid carcinoma changed the outcome or disease-free survival. We suggest that a diagnosis of thyroglossal carcinoma should be followed by a detailed evaluation of the thyroid gland. In the absence of clinical and radiological thyroid alterations, follow-up as for thyroid cancer is the correct management.