Prognostic significance of increased bone marrow microcirculation in newly diagnosed multiple myeloma: results of a prospective DCE-MRI study

详细信息    查看全文

• 作者：Maximilian Merz ; Thomas M. Moehler ; Judith Ritsch ; Tobias Bäuerle…
• 关键词：Multiple myeloma ; Magnetic resonance imaging ; Angiogenesis ; Vertebral fracture ; Dynamic contrast ; enhanced MRI
• 刊名：European Radiology
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：26
• 期：5
• 页码：1404-1411
• 全文大小：533 KB
• 参考文献：1.Engelhardt M, Terpos E, Kleber M et al (2014) European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma. Haematologica 99:232–242CrossRef PubMed PubMedCentral
  2.Chng WJ, Dispenzieri A, Chim CS et al (2014) IMWG consensus on risk stratification in multiple myeloma. Leukemia 28:269–277CrossRef PubMed
  3.Rajkumar SV (2013) Multiple myeloma: 2013 update on diagnosis, risk-stratification, and management. Am J Hematol 88:226–235CrossRef PubMed
  4.Pratt G, Jenner M, Owen R et al (2014) Updates to the guidelines for the diagnosis and management of multiple myeloma. Br J Haematol 167:131–133CrossRef PubMed
  5.Mikhael JR, Dingli D, Roy V et al (2013) Management of newly diagnosed symptomatic multiple myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines 2013. Mayo Clin Proc 88:360–376CrossRef PubMed
  6.Coleman RE (2001) Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 27:165–176CrossRef PubMed
  7.Hose D, Moreaux J, Meissner T et al (2009) Induction of angiogenesis by normal and malignant plasma cells. Blood 114:128–143CrossRef PubMed
  8.Rajkumar SV, Leong T, Roche PC et al (2000) Prognostic value of bone marrow angiogenesis in multiple myeloma. Clin Cancer Res 6:3111–3116PubMed
  9.Rajkumar SV, Mesa RA, Fonseca R et al (2002) Bone marrow angiogenesis in 400 patients with monoclonal gammopathy of undetermined significance, multiple myeloma, and primary amyloidosis. Clin Cancer Res 8:2210–2216PubMed
  10.Hillengass J, Zechmann C, Bauerle T et al (2009) Dynamic contrast-enhanced magnetic resonance imaging identifies a subgroup of patients with asymptomatic monoclonal plasma cell disease and pathologic microcirculation. Clin Cancer Res 15:3118–3125CrossRef PubMed
  11.Hillengass J, Wasser K, Delorme S et al (2007) Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma. Clin Cancer Res 13:475–481CrossRef PubMed
  12.Bhutani M, Turkbey B, Tan E et al (2014) Bone marrow angiogenesis in myeloma and its precursor disease: a prospective clinical trial. Leukemia 28:413–416CrossRef PubMed
  13.Dutoit JC, Vanderkerken MA, Verstraete KL (2013) Value of whole body MRI and dynamic contrast enhanced MRI in the diagnosis, follow-up and evaluation of disease activity and extent in multiple myeloma. Eur J Radiol 82:1444–1452CrossRef PubMed
  14.Merz M, Ritsch J, Kunz C et al (2015) Dynamic contrast-enhanced magnetic resonance imaging for assessment of antiangiogenic treatment effects in multiple myeloma. Clin Cancer Res 21:106–112CrossRef PubMed
  15.Moehler TM, Hawighorst H, Neben K et al (2001) Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging. Int J Cancer 93:862–868CrossRef PubMed
  16.Zwick S, Brix G, Tofts PS et al (2010) Simulation-based comparison of two approaches frequently used for dynamic contrast-enhanced MRI. Eur Radiol 20:432–442CrossRef PubMed
  17.Zamagni E, Cavo M (2012) The role of imaging techniques in the management of multiple myeloma. Br J Haematol 159:499–513PubMed
  18.Song MK, Chung JS, Lee JJ et al (2014) Magnetic resonance imaging pattern of bone marrow involvement as a new predictive parameter of disease progression in newly diagnosed patients with multiple myeloma eligible for autologous stem cell transplantation. Br J Haematol 165:777–785CrossRef PubMed
  19.Regelink JC, Minnema MC, Terpos E et al (2013) Comparison of modern and conventional imaging techniques in establishing multiple myeloma-related bone disease: a systematic review. Br J Haematol 162:50–61CrossRef PubMed
  20.Moulopoulos LA, Dimopoulos MA, Christoulas D et al (2010) Diffuse MRI marrow pattern correlates with increased angiogenesis, advanced disease features and poor prognosis in newly diagnosed myeloma treated with novel agents. Leukemia 24:1206–1212CrossRef PubMed
  21.Dutoit JC, Vanderkerken MA, Anthonissen J et al (2014) The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma. Eur Radiol 24:2754–2765CrossRef PubMed
  22.Hillengass J, Zechmann CM, Nadler A et al (2008) Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma. Int J Cancer 122:2871–2875CrossRef PubMed
  23.Neben K, Jauch A, Hielscher T et al (2013) Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load. J Clin Oncol 31:4325–4332CrossRef PubMed
  24.Kumar S, Witzig TE, Timm M et al (2004) Bone marrow angiogenic ability and expression of angiogenic cytokines in myeloma: evidence favoring loss of marrow angiogenesis inhibitory activity with disease progression. Blood 104:1159–1165CrossRef PubMed
  25.Tanaka Y, Abe M, Hiasa M et al (2007) Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res 13:816–823CrossRef PubMed
  26.Savvopoulou V, Maris TG, Vlahos L et al (2008) Differences in perfusion parameters between upper and lower lumbar vertebral segments with dynamic contrast-enhanced MRI (DCE MRI). Eur Radiol 18:1876–1883CrossRef PubMed
  27.Hillengass J, Stieltjes B, Bauerle T et al (2011) Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals. Acta Radiol 52:324–330CrossRef PubMed
  28.Vogel MN, Weisel K, Maksimovic O et al (2009) Pathologic fractures in patients with multiple myeloma undergoing bisphosphonate therapy: incidence and correlation with course of disease. AJR Am J Roentgenol 193:656–661CrossRef PubMed
  29.Larocca A, Child JA, Cook G et al (2013) The impact of response on bone-directed therapy in patients with multiple myeloma. Blood 122:2974–2977CrossRef PubMed
  30.Terpos E, Morgan G, Dimopoulos MA et al (2013) International Myeloma Working Group recommendations for the treatment of multiple myeloma-related bone disease. J Clin Oncol 31:2347–2357CrossRef PubMed
  31.Huang SY, Chen BB, Lu HY et al (2012) Correlation among DCE-MRI measurements of bone marrow angiogenesis, microvessel density, and extramedullary disease in patients with multiple myeloma. Am J Hematol 87:837–839CrossRef PubMed
  32.Kumar S, Gertz MA, Dispenzieri A et al (2004) Prognostic value of bone marrow angiogenesis in patients with multiple myeloma undergoing high-dose therapy. Bone Marrow Transplant 34:235–239CrossRef PubMed
  33.Bhatti SS, Kumar L, Dinda AK et al (2006) Prognostic value of bone marrow angiogenesis in multiple myeloma: use of light microscopy as well as computerized image analyzer in the assessment of microvessel density and total vascular area in multiple myeloma and its correlation with various clinical, histological, and laboratory parameters. Am J Hematol 81:649–656CrossRef PubMed
  34.Andrulis M, Bauerle T, Goldschmidt H et al (2014) Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology. Eur J Radiol 83:970–974CrossRef PubMed
  35.Usmani SZ, Mitchell A, Waheed S et al (2013) Prognostic implications of serial 18-fluoro-deoxyglucose emission tomography in multiple myeloma treated with total therapy 3. Blood 121:1819–1823CrossRef PubMed PubMedCentral
  
• 作者单位：Maximilian Merz (1) (2)
  Thomas M. Moehler (1)
  Judith Ritsch (1)
  Tobias Bäuerle (3)
  Christian M. Zechmann (4)
  Barbara Wagner (2)
  Anna Jauch (5)
  Dirk Hose (2)
  Christina Kunz (6)
  Thomas Hielscher (6)
  Hendrik Laue (7)
  Hartmut Goldschmidt (2) (8)
  Stefan Delorme (1)
  Jens Hillengass (1) (2)
  
  1. German Cancer Research Center, Department of Radiology, Heidelberg, Germany
  2. Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
  3. Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany
  4. Rinecker Proton Therapy, München, Germany
  5. Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
  6. German Cancer Research Center, Department of Biostatistics, Heidelberg, Germany
  7. Fraunhofer MEVIS, Bremen, Germany
  8. National Center for Tumor Diseases, Heidelberg, Germany
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Imaging and Radiology
  Diagnostic Radiology
  Interventional Radiology
  Neuroradiology
  Ultrasound
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1084

文摘

Objectives Aim of this prospective study was to investigate prognostic significance of increased bone marrow microcirculation as detected by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for survival and local complications in patients with multiple myeloma (MM).