The role of mannose binding lectin on fever episodes in pediatric oncology patients

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• 作者：Ferenc Fekete ; Bal谩zs Fadgyas ; 脡va Papp ; 脕gnes Szil谩gyi…
• 关键词：MBL ; Polymorphism ; Febrile neutropenia ; Oncohematology
• 刊名：Pathology & Oncology Research
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：22
• 期：1
• 页码：139-143
• 全文大小：242 KB
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• 作者单位：Ferenc Fekete (1)
  Bal谩zs Fadgyas (2)
  脡va Papp (3)
  脕gnes Szil谩gyi (4)
  Zolt谩n Proh谩szka (4)
  Brigitta M眉ller (1)
  G谩bor Kov谩cs (5)
  
  1. Department of Hematology, Heim P谩l Children鈥檚 Hospital, Madar谩sz Street Building, Madar谩sz utca 22-24, Budapest, 1131, Hungary
  2. Department of Pediatric Surgery and Traumatology, Heim P谩l Children鈥檚 Hospital, Budapest, Hungary
  3. National Institute of Psychiatry and Addictions, Gyula Ny铆r艖 Hospital, Budapest, Hungary
  4. 3rd Department of Internal Medicine, Research Laboratory, Semmelweis University, Budapest, Hungary
  5. 2nd Department of Pediatrics, Hematology Unit, Semmelweis University, Budapest, Hungary
  
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807

文摘

Despite significant changes in pediatric oncological therapy, mortality is still high, mainly due to infections. Complement system as an ancient immune defense against microorganisms plays a significant role in surmounting infections, therefore, deficiency of its components may have particular importance in malignancies. The present paper assesses the effect of promoter (X/Y) and exon 1 (A/0) polymorphisms of the MBL2 gene altering mannose binding lectin (MBL) serum level in pediatric oncological patients with febrile neutropenia. Furthermore, frequency distribution of MBL2 alleles in children with malignancies and age-matched controls was analysed. Fifty-four oncohematological patients and 53 children who had undergone pediatric surgery were enrolled into this retrospective study. No significant differences were found in the frequency of MBL2 alleles between the hemato-oncologic and control group. The average duration of fever episodes was significantly shorter (p = 0.035) in patients carrying genotypes (AY/AY and AY/AX) that encode normal MBL level, compared to individuals with genotypes associated with lower functional MBL level (AX/AX, AY/0, AX/0, or 0/0) (days, median (IQ range) 3.7(0鈥?.4) vs. 5.0(3.8鈥?.6), respectively). In conclusion, our data suggest that MBL2 genotypes may influence the course of febrile neutropenia in pediatric patients with malignancies, and may contribute to clarification of the importance of MBL in infections. Keywords MBL Polymorphism Febrile neutropenia Oncohematology