Simultaneous pancreas–kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression

详细信息    查看全文

• 作者：Roel Bijkerk ; Pieter van der Pol ; Meriem Khairoun…
• 关键词：Diabetic nephropathy ; Mannan ; binding lectin ; MBL ; Simultaneous pancreas–kidney transplantation ; Type 1 diabetes ; Vascular injury ; VEGF
• 刊名：Diabetologia
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：59
• 期：4
• 页码：853-858
• 全文大小：420 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Internal Medicine
  Metabolic Diseases
  Human Physiology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0428

文摘

Aims/hypothesis High levels of circulating mannan-binding lectin (MBL) are associated with the development of diabetic nephropathy and hyperglycaemia-induced vasculopathy. Here, we aimed to assess the effect of glycaemic control on circulating levels of MBL and the relationship of these levels with vascular damage.