High rate of in-stent restenosis after coronary intervention in carriers of the mutant mannose-binding lectin allele

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• 作者：Zsolt Bagyura ; Loretta Kiss ; Balázs Berta ; Ágnes Szilágyi…
• 关键词：In ; stent restenosis ; MBL genetic variant ; Bare metal stent ; Gene association ; Cardiology
• 刊名：BMC Cardiovascular Disorders
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：388KB
• 刊物主题：Cardiology; Cardiac Surgery; Angiology; Blood Transfusion Medicine; Internal Medicine; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1471-2261
• 卷排序：17

文摘

BackgroundIn-stent restenosis occurs in 10–30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57) are known to modulate the bioavailability of the MBL protein. Our aim was to identify the association of these polymorphisms of the MBL gene in the occurrence of in-stent restenosis after coronary artery bare metal stent implantation.