The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study

详细信息    查看全文

• 作者：Feiyu Li (1) (2)
  Mary McGrae McDermott (3)
  Debiao Li (4)
  Timothy J Carroll (4)
  Daniel S Hippe (2)
  Christopher M Kramer (5)
  Zhaoyang Fan (4)
  Xihai Zhao (2)
  Thomas S Hatsukami (6)
  Baocheng Chu (2)
  Jinnan Wang (7)
  Chun Yuan (2)
  
• 刊名：Journal of Cardiovascular Magnetic Resonance
• 出版年：2010
• 出版时间：December 2010
• 年：2010
• 卷：12
• 期：1
• 全文大小：1322KB
• 参考文献：1. Hirsch AT, Criqui MH, Treat-Jacobson D, Regensteiner JG, Creager MA, Olin JW, Krook SH, Hunninghake DB, Comerota AJ, Walsh ME, McDermott MM, Hiatt WR: Peripheral arterial disease detection, awareness, and treatment in primary care. / JAMA 2001, 286:1317-324. CrossRef
  2. Criqui MH, Langer RD, Fronek A, Feigelson HS, Klauber MR, McCann TJ, Browner D: Mortality over a period of 10 years in patients with peripheral arterial disease. / N Engl J Med 1992, 326:381-86. CrossRef
  3. Cimminiello C: PAD. Epidemiology and pathophysiology. / Thromb Res 2002, 106:V295-01. CrossRef
  4. Lumsden AB, Rice TW, Chen C, Zhou W, Lin PH, Bray P, Morrisett J, Nambi V, Ballantyne C: Peripheral arterial occlusive disease: magnetic resonance imaging and the role of aggressive medical management. / World J Surg 2007, 31:695-04. CrossRef
  5. Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, Tran N, Polissar NL, Isaac C, Ferguson MS, Garden GA, Cramer SC, Maravilla KR, Hashimoto B, Hatsukami TS: Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results. / Stroke 2006, 37:818-23. CrossRef
  6. Davies MJ, Thomas AC: Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. / Br Heart J 1985, 53:363-73. CrossRef
  7. Guzman RJ, Brinkley DM, Schumacher PM, Donahue RM, Beavers H, Qin X: Tibial artery calcification as a marker of amputation risk in patients with peripheral arterial disease. / J Am Coll Cardiol 2008, 51:1967-974. CrossRef
  8. Mintz GS, Popma JJ, Pichard AD, Kent KM, Satler LF, Chuang YC, DeFalco RA, Leon MB: Limitations of angiography in the assessment of plaque distribution in coronary artery disease: a systematic study of target lesion eccentricity in 1446 lesions. / Circulation 1996, 93:924-31.
  9. Yamagishi M, Terashima M, Awano K, Kijima M, Nakatani S, Daikoku S, Ito K, Yasumura Y, Miyatake K: Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome. / J Am Coll Cardiol 2000, 35:106-11. CrossRef
  10. Ohara T, Toyoda K, Otsubo R, Nagatsuka K, Kubota Y, Yasaka M, Naritomi H, Minematsu K: Eccentric stenosis of the carotid artery associated with ipsilateral cerebrovascular events. / AJNR Am J Neuroradiol 2008, 29:1200-203. CrossRef
  11. Nair P, Gruberg L, Beyar R: The eccentric lumenology. / Acute Card Care 2006, 8:87-4. CrossRef
  12. Saam T, Ferguson MS, Yarnykh VL, Takaya N, Xu D, Polissar NL, Hatsukami TS, Yuan C: Quantitative evaluation of carotid plaque composition by in vivo MRI. / Arterioscler Thromb Vasc Biol 2005, 25:234-39. CrossRef
  13. Cai JM, Hatsukami TS, Ferguson MS, Small R, Polissar NL, Yuan C: Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging. / Circulation 2002, 106:1368-373. CrossRef
  14. Kramer CM, Cerilli LA, Hagspiel K, DiMaria JM, Epstein FH, Kern JA: Magnetic resonance imaging identifies the fibrous cap in atherosclerotic abdominal aortic aneurysm. / Circulation 2004, 109:1016-021. CrossRef
  15. Sun B, Giddens DP, Long R Jr, Taylor WR, Weiss D, Joseph G, Vega D, Oshinski JN: Characterization of coronary atherosclerotic plaque using multicontrast MRI acquired under simulated in vivo conditions. / J Magn Reson Imaging 2006, 24:833-41. CrossRef
  16. Isbell DC, Meyer CH, Rogers WJ, Epstein FH, DiMaria JM, Harthun NL, Wang H, Kramer CM: Reproducibility and reliability of atherosclerotic plaque volume measurements in peripheral arterial disease with cardiovascular magnetic resonance. / J Cardiovasc Magn Reson 2007, 9:71-6. CrossRef
  17. McDermott MM, Ades P, Guralnik JM, Dyer A, Ferrucci L, Liu K, Nelson M, Lloyd-Jones D, Van Horn L, Garside D, Kibbe M, Domanchuk K, Stein JH, Liao Y, Tao H, Green D, Pearce WH, Schneider JR, McPherson D, Laing ST, McCarthy WJ, Shroff A, Criqui MH: Treadmill exercise and resistance training in patients with peripheral arterial disease with and without intermittent claudication: a randomized controlled trial. / JAMA 2009, 301:165-74. CrossRef
  18. Koktzoglou I, Chung YC, Mani V, Carroll TJ, Morasch MD, Mizsei G, Simonetti OP, Fayad ZA, Li D: Multislice dark-blood carotid artery wall imaging: a 1.5 T and 3.0 T comparison. / J Magn Reson Imaging 2006, 23:699-05. CrossRef
  19. Underhill HR, Yarnykh VL, Hatsukami TS, Wang J, Balu N, Hayes CE, Oikawa M, Yu W, Xu D, Chu B, / et al.: Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths. / Radiology 2008, 248:550-60. CrossRef
  20. Kerwin W, Xu D, Liu F, Saam T, Underhill H, Takaya N, Chu B, Hatsukami T, Yuan C: Magnetic resonance imaging of carotid atherosclerosis: plaque analysis. / Top Magn Reson Imaging 2007, 18:371-78. CrossRef
  21. Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. / Biometrics 1986, 42:121-30. CrossRef
  22. Vink A, Schoneveld AH, Richard W, de Kleijn DP, Falk E, Borst C, Pasterkamp G: Plaque burden, arterial remodeling and plaque vulnerability: determined by systemic factors? / J Am Coll Cardiol 2001, 38:718-23. CrossRef
  23. Davies PF: Mechanisms involved in endothelial responses to hemodynamic forces. / Atherosclerosis 1997,131(Suppl):S15-7. CrossRef
  24. Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, Krams R: Effect of shear stress on vascular inflammation and plaque development. / Curr Opin Lipidol 2007, 18:527-33. CrossRef
  25. Just H: Coronary arteriography: current technique and standards of equipment. / Med Prog Technol 1977, 5:119-25.
  26. Kullo IJ, Edwards WD, Schwartz RS: Vulnerable plaque: pathobiology and clinical implications. / Ann Intern Med 1998, 129:1050-060.
  27. Shin J, Edelberg JE, Hong MK: Vulnerable atherosclerotic plaque: clinical implications. / Curr Vasc Pharmacol 2003, 1:183-04. CrossRef
  28. Virmani R, Burke AP, Farb A, Kolodgie FD: Pathology of the vulnerable plaque. / J Am Coll Cardiol 2006, 47:C13-8. CrossRef
  29. Ambrose JA, Winters SL, Stern A, Eng A, Teichholz LE, Gorlin R, Fuster V: Angiographic morphology and the pathogenesis of unstable angina pectoris. / J Am Coll Cardiol 1985, 5:609-16. CrossRef
  30. Abedin M, Tintut Y, Demer LL: Vascular calcification: mechanisms and clinical ramifications. / Arterioscler Thromb Vasc Biol 2004, 24:1161-170. CrossRef
  31. Niskanen L, Siitonen O, Suhonen M, Uusitupa MI: Medial artery calcification predicts cardiovascular mortality in patients with NIDDM. / Diabetes Care 1994, 17:1252-256. CrossRef
  
• 作者单位：Feiyu Li (1) (2)
  Mary McGrae McDermott (3)
  Debiao Li (4)
  Timothy J Carroll (4)
  Daniel S Hippe (2)
  Christopher M Kramer (5)
  Zhaoyang Fan (4)
  Xihai Zhao (2)
  Thomas S Hatsukami (6)
  Baocheng Chu (2)
  Jinnan Wang (7)
  Chun Yuan (2)
  
  1. Department of Radiology, Peking University First Hospital, Beijing, China
  2. Department of Radiology, University of Washington, Seattle, WA, USA
  3. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  4. Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
  5. Departments of Radiology and Medicine, University of Virginia, Charlottesville, VA, USA
  6. Department of Surgery, University of Washington, Seattle, WA, USA
  7. Clinical Sites Research Program, Philips Research North America, Briarcliff Manor, NY, USA
  

文摘

Background Atherosclerotic plaque morphology and components are predictors of subsequent cardiovascular events. However, associations of plaque eccentricity with plaque morphology and plaque composition are unclear. This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR). Methods Twenty-eight subjects with an ankle-brachial index less than 1.00 were examined with 1.5T high-spatial-resolution, multi-contrast weighted CMR. One hundred and eighty diseased locations of the proximal superficial femoral artery (about 40 mm) were analyzed. The eccentric lesion was defined as [(Maximum wall thickness- Minimum wall thickness)/Maximum wall thickness] ?0.5. The arterial morphology and plaque components were measured using semi-automatic image analysis software. Results One hundred and fifteen locations were identified as eccentric lesions and sixty-five as concentric lesions. The eccentric lesions had larger wall but similar lumen areas, larger mean and maximum wall thicknesses, and more calcification and lipid rich necrotic core, compared to concentric lesions. For lesions with the same lumen area, the degree of eccentricity was associated with an increased wall area. Eccentricity (dichotomous as eccentric or concentric) was independently correlated with the prevalence of calcification (odds ratio 3.78, 95% CI 1.47-9.70) after adjustment for atherosclerotic risk factors and wall area. Conclusions Plaque eccentricity is associated with preserved lumen size and advanced plaque features such as larger plaque burden, more lipid content, and increased calcification in the superficial femoral artery.