KIT and BRAF Mutational Status in a Patient with a Synchronous Lentigo Maligna Melanoma and a Gastrointestinal Stromal Tumor

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• 作者：Dr Rubeta N. Matin (1)
  David Gonzalez (2)
  Lisa Thompson (2)
  Sally R. Lambert (1)
  Farrah Bakr (1)
  Nathalie Dhomen (3)
  Richard Marais (3)
  Jane M. McGregor (1)
  Peter Szlosarek (4)
  Rino Cerio (5)
  Catherine A. Harwood (1)
  
• 刊名：American Journal of Clinical Dermatology
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：13
• 期：1
• 页码：64-65
• 全文大小：207KB
• 参考文献：1. Curtin JA, Busam K, Pinkel D, et al. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 2006; 24 (26): 4340鈥? CrossRef
  2. Wyman K, Atkins MB, Prieto V, et al. Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 2006; 106 (9): 2005鈥?1 CrossRef
  3. Jiang X, Zhou J, Yuen NK, et al. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res 2008; 14 (23): 7726鈥?2 CrossRef
  4. Li FP, Fletcher JA, Heinrich MC, et al. Familial gastrointestinal stromal tumor syndrome: phenotypic and molecular features in a kindred. J Clin Oncol 2005; 23 (12): 2735鈥?3 CrossRef
  5. Beadling C, Jacobson-Dunlop E, Hodi FS, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008; 14 (21): 6821鈥? CrossRef
  6. Torres-Cabala CA, Wang WL, Trent J, et al. Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type. Mod Pathol 2009; 22 (11): 1446鈥?6 CrossRef
  7. Antonescu CR, Busam KJ, Francone TD, et al. L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 2007; 121 (2): 257鈥?4 CrossRef
  
• 作者单位：Dr Rubeta N. Matin (1)
  David Gonzalez (2)
  Lisa Thompson (2)
  Sally R. Lambert (1)
  Farrah Bakr (1)
  Nathalie Dhomen (3)
  Richard Marais (3)
  Jane M. McGregor (1)
  Peter Szlosarek (4)
  Rino Cerio (5)
  Catherine A. Harwood (1)
  
  1. Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, E1 2AT, 4 Newark Street, London, UK
  2. Section of Haemato-Oncology, The Institute of Cancer Research, Sutton, UK
  3. Section of Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK
  4. Barts Cancer Institute, Queen Mary University of London, London, UK
  5. ICMS Pathology Group, Barts and The London School of Medicine and Dentistry, Institute of Pathology, London, UK
  

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