Cytokine gene polymorphisms in ischaemic heart disease: investigation using family-based tests of association

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• 作者：Paul G. McGlinchey ; Mark S. Spence ; Chris C. Patterson ; Adrian R. Allen ; Gillian Murphy ; David A. Savage ; A. Peter Maxwell and Pascal P. McKeown
• 关键词：Ischaemic heart disease ; Inflammation ; Gene polymorphism ; Interleukin 6 ; Interleukin 10 ; Transforming growth factor ; 1
• 刊名：Journal of Molecular Medicine
• 出版年：2004
• 出版时间：November 2004
• 年：2004
• 卷：82
• 期：11
• 页码：756-761
• 全文大小：181 KB
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Molecular Medicine
  Internal Medicine
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1440

文摘

Atherosclerosis has an inflammatory basis, with cytokines, cellular adhesion molecules and pro-inflammatory cells having important roles in the initiation and progression of this process. Interleukin (IL) 6, IL-10 and transforming growth factor (TGF) ₁ have been proposed as important modulators of the atherosclerotic process, with IL-6 having a pro-inflammatory, atherogenic effect and IL-10 and TGF-₁ having anti-inflammatory, protective roles. The possible role of functional polymorphisms in the promoter regions of the IL-6, IL-10 and TGF-₁ genes in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family-based tests of association. We genotyped 1,012 individuals from 386 families with at least one member prematurely affected with IHD. Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test, no association between any of the IL-6 –174G/C, IL-10 –1082G/A and TGF-₁ –509C/T polymorphisms and IHD was found. Our data demonstrate that, in an Irish population, these polymorphisms are not associated with IHD.