Renal insufficiency is associated with an increased risk of papillary renal cell carcinoma histology
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- 作者：Solomon L. Woldu (1)
Aaron C. Weinberg (1)
Arindam RoyChoudhury (2)
Herbert Chase (3)
Sean D. Kalloo (4)
James M. McKiernan (1)
G. Joel DeCastro (1) - 关键词：Renal cell carcinoma ; Papillary ; Renal insufficiency ; Risk factor
- 刊名：International Urology and Nephrology
- 出版年：2014
- 出版时间：November 2014
- 年：2014
- 卷：46
- 期：11
- 页码：2127-2132
- 全文大小：321 KB
- 参考文献：1. Siegel R, Naishadham D, Jemal A (2013) Cancer statistics. CA Cancer J Clin 63:11-0 g/10.3322/caac.21166" target="_blank" title="It opens in new window">CrossRef
2. Jayson M, Sanders H (1998) Increased incidence of serendipitously discovered renal cell carcinoma. Urology 51:203-05 g/10.1016/S0090-4295(97)00506-2" target="_blank" title="It opens in new window">CrossRef
3. Rini BI, Campbell SC, Escudier B (2009) Renal cell carcinoma. Lancet 373:1119-132 g/10.1016/S0140-6736(09)60229-4" target="_blank" title="It opens in new window">CrossRef
4. Schmidt L, Junker K, Nakaigawa N et al (1999) Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene 18:2343-350 g/10.1038/sj.onc.1202547" target="_blank" title="It opens in new window">CrossRef
5. Schmidt LS, Nickerson ML, Angeloni D et al (2004) Early onset hereditary papillary renal carcinoma: germline missense mutations in the tyrosine kinase domain of the met proto-oncogene. J Urol 172:1256-261 g/10.1097/01.ju.0000139583.63354.e0" target="_blank" title="It opens in new window">CrossRef
6. Stewart JH, Buccianti G, Agodoa L et al (2003) Cancers of the kidney and urinary tract in patients on dialysis for end-stage renal disease: analysis of data from the United States, Europe, and Australia and New Zealand. J Am Soc Nephrol 14:197-07 g/10.1097/01.ASN.0000039608.81046.81" target="_blank" title="It opens in new window">CrossRef
7. Bussolati B, Bruno S, Grange C et al (2005) Isolation of renal progenitor cells from adult human kidney. Am J Pathol 166:545-55 g/10.1016/S0002-9440(10)62276-6" target="_blank" title="It opens in new window">CrossRef
8. Schwartz JDDFH JM, Wilson GD, Wolforth SC, Rooney MT, Wei L, Zhang PL (2013) CD133 Staining detects acute kidney injury and differentiates clear cell papillary renal cell carcinoma from other renal tumors. ISRN Biomark 2013, 8
9. Levey AS, Stevens LA, Schmid CH et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604-12 g/10.7326/0003-4819-150-9-200905050-00006" target="_blank" title="It opens in new window">CrossRef
10. Levey AS, Coresh J, Balk E et al (2003) National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med 139:137-47 g/10.7326/0003-4819-139-2-200307150-00013" target="_blank" title="It opens in new window">CrossRef
11. Campbell SCLBR (2012) Malignant renal tumors. In: Wein AJ (ed) Campbell-Walsh urology, vol 3, 10th edn. Elsevier, Philadelphia PA, p 4320
12. Ximing J, Yang KD, Jia L, Gersbach E, Lin F, Shen S, Teh BT (2013) Is papillary renal cell carcinoma derived from proximal convoluted tubules?. United States and Canadian Academy of Pathology Annual Meeting, Baltimore, MA
13. Renehan AG, Tyson M, Egger M et al (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371:569-78 g/10.1016/S0140-6736(08)60269-X" target="_blank" title="It opens in new window">CrossRef
14. Hajjar I, Kotchen TA (2003) Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-000. J Am Med Assoc 290:199-06 g/10.1001/jama.290.2.199" target="_blank" title="It opens in new window">CrossRef
15. Fryzek JP, Poulsen AH, Johnsen SP et al (2005) A cohort study of antihypertensive treatments and risk of renal cell cancer. Br J Cancer 92:1302-306 g/10.1038/sj.bjc.6602490" target="_blank" title="It opens in new window">CrossRef
16. Lipworth L, Tarone RE, McLaughlin JK (2006) The epidemiology of renal cell carcinoma. J Urol 176:2353-358 g/10.1016/j.juro.2006.07.130" target="_blank" title="It opens in new window">CrossRef
17. Ljungberg B, Campbell SC, Choi HY et al (2011) The epidemiology of renal cell carcinoma. Eur Urol 60:615-21 g/10.1016/j.eururo.2011.06.049" target="_blank" title="It opens in new window">CrossRef
18. McCredie M, Pommer W, McLaughlin JK et al (1995) International renal-cell cancer study. II. Analgesics. Int J Cancer 60:345-49 g/10.1002/ijc.2910600312" target="_blank" title="It opens in new window">CrossRef
19. Park JH, Kim YO, Park JH et al (2000) Comparison of acquired cystic kidney disease betwe - 作者单位：Solomon L. Woldu (1)
Aaron C. Weinberg (1)
Arindam RoyChoudhury (2)
Herbert Chase (3)
Sean D. Kalloo (4)
James M. McKiernan (1)
G. Joel DeCastro (1)
1. Department of Urology, Columbia University Medical Center, Herbert Irving Pavilion -11th Floor 161 Ft. Washington Ave, New York, NY, 10032, USA
2. Department of Biostatistics, Columbia University Medical Center, New York, NY, USA
3. Department of Biomedical Informatics, Columbia University Medical Center, New York, NY, USA
4. Department of Nephrology, Columbia University Medical Center, New York, NY, USA - ISSN：1573-2584
文摘
Purpose End-stage renal disease (ESRD) and acquired renal cystic disease associated with dialysis are known risk factors of papillary renal cell carcinoma (pRCC); however, it is not known whether renal insufficiency alone is a risk factor for pRCC. Our aim was to test whether renal insufficiency is associated with an increased preponderance of pRCC. Methods Retrospective review of institutional database to identify all patients who underwent extirpative renal surgery for renal cell carcinoma (RCC) with complete records from 1992 to 2012. We excluded those patients with preoperative ESRD as defined by GFR?2. The dependent variable was histologic RCC subtype. Independent variables included demographic data, comorbidities, and renal functional data. Multivariate analysis by binary logistic regression was used to determine factors that independently were associated with pRCC development. Results A total of 1,226 patients met inclusion criteria, of which 15?% were pRCC. There was a positive association between likelihood of pRCC histology of RCC and increasing preoperative chronic kidney disease (CKD) stage (p?=?0.021). Multivariate regression analysis indicated that male gender, race, and declining renal function categorized both by GFR and CKD stage were independently associated with a higher likelihood of pRCC histology as compared to other RCC histology. Conclusions Within a large cohort of patients with a diagnosis of RCC, declining renal function was independently associated with an increased likelihood of pRCC histology. This finding and the available molecular evidence indicating protein expression similarity between pRCC and resident stem cells, which appear to be upregulated with kidney damage, suggest a possible causal relationship between renal injury and pRCC.