Predicting Cognitive Executive Functioning with Polygenic Risk Scores for Psychiatric Disorders
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- 作者：Chelsie E. Benca ; Jaime L. Derringer ; Robin P. Corley ; Susan E. Young…
- 关键词：Cognitive control ; Executive control ; Polygenic risk scores ; Intermediate phenotypes
- 刊名：Behavior Genetics
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：47
- 期：1
- 页码：11-24
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Clinical Psychology; Health Psychology; Public Health;
- 出版者：Springer US
- ISSN：1573-3297
- 卷排序：47
文摘
Executive functions (EFs) have been proposed as an endophenotype for psychopathology because EF deficits are associated with most psychiatric disorders. To examine this hypothesis, we derived polygenic risk scores for autism, attention-deficit/hyperactive disorder (ADHD), bipolar disorder, major depression (MDD), and schizophrenia, using genome-wide data from the Psychiatric Genomics Consortium as discovery samples. We then examined the relationships between these polygenic risk scores and three separable EF components measured with a latent variable model. We also examined the relationship between genetic risk for ADHD and MDD and their respective symptom counts and lifetime diagnoses. We found no evidence for larger effect sizes for EFs as endophenotypes for psychiatric disorders. However, larger sample sizes will be important in examining this relationship further.